GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms.

PMID:10198000

Transcriptional organization of the czc heavy-metal homeostasis determinant from Alcaligenes eutrophus.

Establishes in Cupriavidus metallidurans CH34 (formerly Alcaligenes eutrophus CH34) that czcI is transcribed as a 400-nucleotide transcript and as part of the czcNIC-czcCBA heavy-metal homeostasis determinant induced by Zn2+, Co2+, and Cd2+.

"Induction of czcN, czcI, czcCBA, and czcDRS followed a similar pattern: transcription was induced best by 300 microM zinc, less by 300 microM cobalt, and only slightly by 300 microM cadmium."

file:VARPD/czcI/czcI-notes.md

Curation Notes for czcI (VPARA_44920, A0A0H2LVR9) in Variovorax paradoxus TBEA6

file:VARPD/czcI/czcI-uniprot.txt

UniProtKB record for Variovorax paradoxus TBEA6 czcI (A0A0H2LVR9)

VPARA_44920 is a 123-amino-acid protein classified in the CzcI heavy-metal resistance modulator family (NCBIfam:NF045614 efflu_CzcI_Cupr; Pfam:PF11162 DUF2946; InterPro:IPR055013 CzcI) with a predicted N-terminal signal peptide (residues 1-20) and mature periplasmic chain (residues 21-123).

"DR NCBIfam; NF045614; efflu_CzcI_Cupr; 1."
Contains the DUF2946/CzcI domain (Pfam:PF11162; InterPro:IPR055013).

"DR Pfam; PF11162; DUF2946; 1."
Classified in InterPro family IPR055013 (CzcI).

"DR InterPro; IPR055013; CzcI."
Possesses a predicted N-terminal signal peptide (residues 1-20) and mature periplasmic chain (residues 21-123) with no transmembrane segments.

"FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..123 FT /evidence="ECO:0000256|SAM:SignalP""