Gene Ontology annotation based on Enzyme Commission mapping

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:15131269

The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein.

Human UbcH8 (UBE2L6) is charged with ISG15 by E1-ISG15 and is a major E2 for ISG15 conjugation in vivo (siRNA).

"We therefore conclude that UbcH8 serves as a major E2 enzyme for ISG15 conjugation in vivo ."
UbcH8 also supports ubiquitin conjugation with a HECT E3.

"Rsp5p catalyzed efficient polyubiquitination of WBP2 in the presence of E1 Ub and UbcH8"

PMID:28724761

ISG15 Modulates Type I Interferon Signaling and the Antiviral Response during Hepatitis E Virus Replication.

Knockdown of UBE1L or UBE2L6 did not alter HEV sensitivity to type I interferon.

"We also observed that loss of ISGylating enzymes (UBE1L and UBE2L6) did not affect the HEV type I IFN sensitivity."

file:RABIT/G1TUN6/G1TUN6-uniprot.txt

UniProt record G1TUN6

file:RABIT/G1TUN6/G1TUN6-bioinformatics/RESULTS.md

G1TUN6 sequence comparison and PANTHER/PAINT placement

file:RABIT/G1TUN6/G1TUN6-deep-research-falcon.md

Falcon deep research on UBE2L6 (G1TUN6)