Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells.

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells.

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.

Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.

COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1.

Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease.

Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

A proteome-scale map of the SARS-CoV-2-human contactome.