Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family.
Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells.
Regulation of transferrin receptor 2 protein levels by transferrin.
HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron.
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HFE co-expression enhances TFR2 transferrin affinity and transferrin-dependent iron uptake.
"increased affinity for diferric transferrin, increased transferrin-dependent"
A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis.
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.
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HFE, TFR2, and HJV physically form a membrane complex relevant to hepcidin regulation.
"that HFE, TfR2, and HJV form a multi-protein membrane complex."
CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression.
Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms.
A reference map of the human binary protein interactome.
TFR2 dimer binds 2xholoTF
Transferrin receptor 2 is crucial for iron sensing in human hepatocytes.
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Holoferric transferrin increases hepcidin expression in primary human hepatocytes, where TFR2 and hepcidin expression correlate.
"Hepcidin expression was increased in primary human hepatocytes following 24-h"
Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.
UniProtKB record for human TFR2 (Q9UP52)
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Reviewed TFR2-alpha is a homodimeric type-II cell-membrane protein; isoform beta lacks the transmembrane domain and is cytoplasmic.
"Cell membrane; Single-pass type II membrane"
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UniProt summarizes direct transferrin-bound iron uptake by TFR2.
"Mediates cellular uptake of transferrin-bound iron"
Manual deep research synthesis for human TFR2
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Primary evidence converges on a transferrin-binding receptor with both endocytic uptake and hepatic hepcidin-regulatory roles.
"TFR2 is a hepatocyte transferrin-saturation sensor required for an appropriate hepcidin"
Manual TFR2 curation notes
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Records data provenance, provider status, annotation decisions, and evidence boundaries.
"membrane TFR2-alpha binds transferrin and can mediate endocytic iron"