Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Initial characterization of the nascent polypeptide-associated complex in yeast.
The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane.
Identification of novel phospholipid binding proteins in Saccharomyces cerevisiae.
Proteome survey reveals modularity of the yeast cell machinery.
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex.
High-quality binary protein interaction map of the yeast interactome network.
Functional Dissection of the Nascent Polypeptide-Associated Complex in Saccharomyces cerevisiae.
An inter-species protein-protein interaction network across vast evolutionary distance.
The social and structural architecture of the yeast protein interactome.
Functional similarities and differences among subunits of the nascent polypeptide-associated complex (NAC) of Saccharomyces cerevisiae.
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A 2024 yeast NAC study found that the core Nac-alpha domain was sufficient to rescue growth of cells expressing low beta-NAC levels, consistent with EGD2's central contribution in that assay being alpha/beta dimerization and beta-subunit stabilization.
"Together, our results suggest that only the core domain of Nacα suffices to overcome the growth defect of strains expressing only low levels of the beta subunit"
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The same study found that Nac-alpha truncations removing N- or C-terminal regions, including the C-terminal UBA-domain segment, still supported growth as well as full-length Nac-alpha in the tested complementation assay.
"Deletions removing N-terminal or C-terminal segments that included the ubiquitin association domain supported growth as well as full-length protein (Figure 6(c))."
The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo.
Falcon deep research synthesis for EGD2
PANTHER family PTHR21713 NAC alpha subunit metadata