Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells.
Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1.
Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis.
PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B.
PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways.
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis.
The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation.
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.
Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC.
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.
Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells.
Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways.
Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation.
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.
Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.
Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain.
A role for mitochondria in NLRP3 inflammasome activation.
The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome.
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.
Inflammasomes in health and disease.
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.
Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction.
Central and overlapping role of Cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells.
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.
Cell volume regulation modulates NLRP3 inflammasome activation.
Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation.
Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion.
Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.
The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.
Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly.
Overexpressed NLRC3 acts as an anti-inflammatory cytosolic protein.
In silico prediction of physical protein interactions and characterization of interactome orphans.
A proteome-scale map of the human interactome network.
Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization.
MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3.
The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus.
Inflammasomes: mechanism of action, role in disease, and therapeutics.
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces.
Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.
A Novel Mutation in the Pyrin Domain of the NOD-like Receptor Family Pyrin Domain Containing Protein 3 in Muckle-Wells Syndrome.
NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma.
Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection.
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.
Inflammasome activation and assembly at a glance.
The AIM2 inflammasome: Sensor of pathogens and cellular perturbations.
Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis.
Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease.
Molecular mechanism for NLRP6 inflammasome assembly and activation.
Expression of a PYCARD/ASC variant lacking exon 2 in Japanese patients with palindromic rheumatism increases interleukin-1β secretion.
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation.
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation.
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.
Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis.
Cleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2.
ASC binds Caspase-8 complex
Caspase-8 cleaves IL1B precursor
Exocytosis of secretory granule lumen proteins
Exocytosis of azurophil granule lumen proteins
NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction
PYCARD recruits procaspase-1 via CARD
SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.
Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines.
The pannexin 1 channel activates the inflammasome in neurons and astrocytes.