Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Characterization of MAD2B and other mitotic spindle checkpoint genes.
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MAD2L2/MAD2B was identified as a novel gene homologous to spindle checkpoint gene MAD2
"we isolated a novel human gene, MAD2B (MAD2L2), which is homologous to the spindle checkpoint gene MAD2"
Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.
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MAD2beta (MAD2L2) identified as binding partner of MDC9 cytoplasmic domain
"a novel MAD2-related protein, MAD2beta, as a binding partner of the MDC9 cytoplasmic domain"
Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1.
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MAD2L2 specifically binds and inhibits Cdh1-APC
"MAD2L2 specifically binds and inhibits Cdh1-APC, paralleling the effect of MAD2 on Cdc20"
MAD2B is an inhibitor of the anaphase-promoting complex.
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MAD2B inhibits both CDH1-APC and CDC20-APC
"MAD2B also inhibits APC. In contrast to MAD2, MAD2B inhibits both CDH1-APC and CDC20-APC"
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Unlike MAD2, MAD2B does not interact with MAD1
"Unlike MAD2, whose interaction with MAD1 is required for mitotic checkpoint control, MAD2B does not interact with MAD1"
Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7.
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hREV7 interacts with both hREV1 and hREV3
"The interaction between hREV1 and hREV7 was identified by the yeast two-hybrid library screening"
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hREV7 homodimerizes
"The homodimerization of hREV7 was also detected in the two-hybrid analysis"
Multiple roles of vertebrate REV genes in DNA repair and recombination.
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REV7 knockout cells show chromosomal instability and hypersensitivity to genotoxic agents
"REV1-/- REV3-/- REV7-/- cells showed spontaneous cell death, chromosomal instability/fragility"
Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1.
MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.
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MAD2B interacts with TCF4 and blocks its transactivation
"Using the TOPFLASH reporter assay, we found that MAD2B blocks TCF4-mediated transactivation"
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MAD2B knockdown induces EMT
"Knockdown of MAD2B in SW480 colorectal cancer cells led to the conversion of epithelial cells to a mesenchymal fibroblastoid phenotype"
Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1.
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REV7 functions as adapter protein to recruit Pol zeta to lesion sites
"Our results highlight the function of REV7 as an adapter protein to recruit Polzeta to a lesion site"
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Crystal structure reveals REV7-REV3 interaction mechanism
"we show the first crystal structure of human REV7 in complex with a fragment of human REV3 polymerase"
CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.
Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypass.
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Pol zeta4 (Rev3-Rev7-PolD2-PolD3) is the fully active form
"The purified four-subunit Pol zeta4 (Rev3-Rev7-PolD2-PolD3) is much more efficient and more processive"
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Complete bypass of cisplatin lesions requires Pol eta insertion and Pol zeta4 extension
"complete bypass of cisplatin lesions requires Pol eta to insert dCTP opposite the 3' guanine and Pol zeta4 to extend the primers"
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
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Shieldin complex comprises REV7 plus SHLD1, SHLD2, SHLD3
"We identified a novel vertebrate-specific protein complex, shieldin, comprising REV7 plus three previously uncharacterized proteins"
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Shieldin promotes NHEJ by restraining DNA end resection
"Shieldin functions as a downstream effector of 53BP1-RIF1 in restraining DNA end resection"
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Shieldin mediates CSR and telomere fusion
"promotes NHEJ-dependent repair of intrachromosomal breaks, immunoglobulin class-switch recombination (CSR), and fusion of unprotected telomeres"
FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection.
Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.
Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B.
Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas.
Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2.
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
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Shigella IpaB targets Mad2L2 to cause cell cycle arrest
"the Shigella effector IpaB, when delivered into epithelial cells, causes cell-cycle arrest by targeting Mad2L2"
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.
The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζ.
Structural insights into the assembly of human translesion polymerase complexes.
A proteome-scale map of the human interactome network.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Formation of Pol zeta complex
REV1 recruits POLZ to damaged DNA
POLK forms quaternary complex with REV1 and POLZ
POLK incorporates dNMP opposite damaged DNA
POLK and POLZ cooperate in elongation
POLI binds REV1 and monoUb-PCNA
POLZ elongates POLI product
Biallelic inactivation of REV7 is associated with Fanconi anemia.
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REV7/MAD2L2 is Fanconi anemia complementation group gene FANCV
"identified REV7 as a previously undescribed FA gene, which we term FANCV"
MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner.
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MAD2L2 protects stalled replication forks from MRE11-dependent resection, independently of shieldin and dependent on REV3L/REV1
"MAD2L2 is essential for the protection of stalled replication forks and their efficient restart after replication stress"
Deep research on MAD2L2
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REV7 dimerization is required for TLS and shieldin functions
"REV7 is an accessory subunit of human Pol zeta together with the catalytic subunit REV3L and replicative subunits POLD2/POLD3; Pol zeta functions as the extender polymerase in translesion synthesis"