rsks-1 (Q9NAH6) manual literature research

No deep-research provider API was available for this session, so this is a manual
literature synthesis from cached publications (publications/PMID_*.md), the UniProt
record (rsks-1-uniprot.txt) and PubMed/PMC full text. All quotes are verbatim.

Identity and family

• RSKS-1 (Y47D3A.16, WBGene00012929) is the single C. elegans p70 ribosomal protein S6
  kinase (S6K) ortholog, 550 aa, AGC kinase family, S6 kinase subfamily
  [UniProt Q9NAH6 "Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily."].
• Domains: protein kinase domain 83-344 (ATP-binding K115; proton acceptor D210), AGC-kinase
  C-terminal domain 345-415, disordered C-terminal tail (UniProt FT lines; PIRSF000605,
  CDD cd05584 STKc_p70S6K).
• T404 corresponds to the TOR-site hydrophobic-motif threonine (T389 in human S6K1)
  PMID:22278922;
  T404A fails to rescue the germline phenotype PMID:22278922.
• Kinase activity has not been measured biochemically for the worm protein; K115Q
  (predicted kinase-dead) behaves as loss of function in axon regrowth (UniProt MUTAGEN 115,
  PMID:24431434).

TORC1 pathway position

• Acts downstream of TOR/RAPTOR in germline progenitor expansion
  PMID:22278922.
• Used as the canonical TORC1 output in a sphingolipid-TORC1 postembryonic development pathway
  PMID:23705068.
• Translation: rsks-1 and ife-2 promote protein biosynthesis but are not required for
  completion of larval development PMID:18804378.

Lifespan and stress

• Loss of S6K extends lifespan PMID:17266679;
  PMID:17266680.
• Lifespan extension of rsks-1 requires pha-4/FoxA PMID:18804378.
• rsks-1 mutation extends lifespan; raga-1 further extends it PMID:20523893.
• HSF-1 mediates rsks-1 longevity PMID:23879233.
• daf-2; rsks-1 synergistic longevity via germline signalling and AAK-2 (PMID:24332851).
• A NOT lifespan annotation from the ife-2 paper (PMID:17277769) could not be checked; the
  abstract does not discuss rsks-1.

Autophagy

• Adult RNAi of rsks-1 reduced LGG-1 autophagic puncta
  PMID:22560223.
  UniProt's text ("RNAi-mediated knockdown in adults causes increase in lgg-1 positive
  autophagic vesicles"; "Negatively regulates autophagy") states the opposite direction from
  the paper; this appears to be a UniProt curation error.
• Sheaffer et al. note rsks-1 mutants do not show increased autophagy
  PMID:18804378.

Development, germline, neurons

• Germline: required germline-autonomously for larval accumulation of germline progenitors
  PMID:22278922.
• Larval development: rsks-1 mutations suppress pha-4 larval lethality
  PMID:18804378.
• Axon regeneration: cell-autonomous inhibitor of axon regrowth acting via AAK-2/AMPK
  PMID:24431434.
  Localized to axon and perikaryon of touch neurons, enriched in the PLM synaptic branch (UniProt SUBCELLULAR LOCATION, PMID:24431434).