hbs (Hibris; Drosophila melanogaster, A1Z9X4) notes

The falcon deep research report (hbs-deep-research-falcon.md) arrived after the wrapper timeout; it agrees with the picture below (Hbs as an IRM adhesion protein acting redundantly with Sns in fusion, with Rst in retinal sorting, and in sensory organ spacing; nephrocyte role unproven).

Identity

• Nephrin-like IgSF transmembrane protein (8 Ig domains, FnIII, 160 aa cytoplasmic tail), paralog of Sns; member of the IRM with Kirre, Rst, Sns.
• PMID:11684662

Myoblast fusion

• PMID:11684661; PMID:11684661
• S2 aggregation: PMID:11684662
• Redundancy with Sns PMID:19270174; PMID:19270174.

Eye

• PMID:20599904; PMID:20599904.
• Cindr: PMID:23027549
• Notch: PMID:22814602; PMID:22814602
• Ommatidial rotation (genetic interaction with Mtl) PMID:21441778.

Curation thoughts

• Core: heterophilic adhesion with Kirre/Rst (cell adhesion mediator activity), myoblast fusion (redundant with Sns), IRM-mediated cell sorting in the pupal eye.
• Notch processing / positive regulation of Notch signaling: Hbs required for Psn maturation (necessity, not catalysis) -> keep non-core.
• Malpighian tubule stellate cell differentiation (PMID:9927461): abstract does not mention hbs -> UNDECIDED.