Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Combined Automated Annotation using Multiple IEA Methods.
The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2.
AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3.
AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.
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DAB2IP transduces TRAF2-induced ASK1-JNK activation
"AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation"
RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation.
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response.
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice.
DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis.
AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling.
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
The unfolded protein response: integrating stress signals through the stress sensor IRE1α.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C.
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DAB2IP acts as GAP for RAB40C in lipid droplet regulation
"A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C"
RAS GAPs stimulate RAS GTPase activity
Deep research summary for DAB2IP
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DAB2IP is a multifunctional tumor suppressor with GAP and scaffold functions
"DAB2IP represents a critical tumor suppressor protein that functions as both an enzymatic Ras GTPase-activating protein (GAP) and a multivalent signaling scaffold"
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DAB2IP inhibits PI3K-AKT while activating ASK1-JNK
"DAB2IP sequesters both AKT1 and MAP3K5 (ASK1) proteins and counterbalances the activity of each kinase"
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DAB2IP loss drives EMT and metastasis
"DAB2IP loss initiates epithelial-to-mesenchymal transition (EMT)"