Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation by the MGI curatorial staff, curated orthology
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Deep research report on mouse Sox2 function and mechanisms
UniProt entry for mouse Sox2 transcription factor
Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3.
Multipotent cell lineages in early mouse development depend on SOX2 function.
Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development.
SOX7 and GATA-4 are competitive activators of Fgf-3 transcription.
Disturbing endoderm signaling to anterior neural plate of vertebrates by the teratogen cadmium.
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain.
Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation.
Sox2 is required for sensory organ development in the mammalian inner ear.
Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.
Role of Sox2 in the development of the mouse neocortex.
SOX2 is a dose-dependent regulator of retinal neural progenitor competence.
Dissecting self-renewal in stem cells with RNA interference.
Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans.
Sox2 is required for development of taste bud sensory cells.
Inhibition of DNA binding of Sox2 by the SUMO conjugation.
Sox2 and Pou2f1 interact to control lens and olfactory placode development.
Zic3 is required for maintenance of pluripotency in embryonic stem cells.
A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells.
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.
Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells.
SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland.
Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation.
Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency.
ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a.
A positive regulatory role for the mSin3A-HDAC complex in pluripotency through Nanog and Sox2.
The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms.
Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis.
The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting.
Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells.
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming.
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.
An Oct4-centered protein interaction network in embryonic stem cells.
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.
Mediator and cohesin connect gene expression and chromatin architecture.
Sall1 regulates embryonic stem cell differentiation in association with nanog.
Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination.
Pluripotency factors regulate definitive endoderm specification through eomesodermin.
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.
lincRNAs act in the circuitry controlling pluripotency and differentiation.
Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2.
Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1.
Deciphering the Sox-Oct partner code by quantitative cooperativity measurements.
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.
The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex.
Cdk1 interplays with Oct4 to repress differentiation of embryonic stem cells into trophectoderm.
Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells.
Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium.
Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells.
Acetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency.
A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.
CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development.
Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.
Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.
Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling.
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.
Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells.
Expression patterns of long noncoding RNAs from Dlk1-Dio3 imprinted region and the potential mechanisms of Gtl2 activation during blastocyst development.
Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.
Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
Nucleoporin insufficiency disrupts a pluripotent regulatory circuit in a pro-arrhythmogenic stem cell line.
Tsukushi is essential for the development of the inner ear.
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.
Involvement of SOX proteins in lens-specific activation of crystallin genes.
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.
Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice.
New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2.
Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells.
The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives.
Mecp2 and Sox2 bind Mir137 gene
Expression of Sox2 in anterior neural plate
Expression of Sox2 in posterior neural plate
Falcon deep research report on mouse Sox2 function