Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification and characterization of human ethanolaminephosphotransferase1.
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Identified human selenoprotein I as hEPT1; recombinant enzyme specifically used CDP-ethanolamine as the phosphobase donor to produce PE, activated by Mn2+ and Mg2+; ubiquitously expressed, highest in cerebellum.
A mutation of EPT1 (SELENOI) underlies a new disorder of Kennedy pathway phospholipid biosynthesis.
EPT1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in humans.
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EPT1 transfers phosphoethanolamine from CDP-ethanolamine to lipid acceptors to make diacyl-PE and ether-linked plasmenyl-PE; loss of EPT1 (patient fibroblasts, EPT1-KO HeLa) reduces PE and plasmenyl-PE, indicating an indispensable role in myelination, neurodevelopment and ether-phospholipid homeostasis.
CDP-ETA and DAG are converted to PE by CEPT1/EPT1