GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:12107093
Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts.
PMID:14718574
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
PMID:16502470
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
PMID:1692625
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.
PMID:16997486
Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease.
PMID:17112520
Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque deposition.
PMID:17188016
Folding, activity and targeting of mutated human cathepsin D that cannot be processed into the double-chain form.
PMID:18337546
Identification and subcellular localization of a new cystinosin isoform.
PMID:1837142
Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease.
PMID:19056867
Large-scale proteomics and phosphoproteomics of urinary exosomes.
PMID:19723497
Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking.
PMID:20551380
Proteomics characterization of extracellular space components in the human aorta.
PMID:22261194
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.
PMID:2350688
Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin.
PMID:23533145
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
PMID:25037231
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
PMID:25204797
Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells.
PMID:27068509
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
PMID:28344315
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
PMID:28493053
Regulation of cathepsin D activity by the FTLD protein progranulin.
PMID:28675934
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PMID:3927292
Cloning and sequence analysis of cDNA for human cathepsin D.
Reactome:R-HSA-2130349
Generation of CLIP from lip10
Reactome:R-HSA-2130706
MHC class II antigen processing
Reactome:R-HSA-2132295
MHC class II antigen presentation
Reactome:R-HSA-2471621
Endostatin degradation by cathepsins
Reactome:R-HSA-6798745
Exocytosis of tertiary granule lumen proteins
Reactome:R-HSA-6798749
Exocytosis of specific granule lumen proteins
Reactome:R-HSA-6800434
Exocytosis of ficolin-rich granule lumen proteins
Reactome:R-HSA-9023846
Estrogen-responsive CTSD expression
PMID:8393577
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
PMID:27703010
Hepatic ZIP14-mediated Zinc Transport Contributes to Endosomal Insulin Receptor Trafficking and Glucose Metabolism.
PMID:19710420
Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity.
PMID:11779865
Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D.
file:human/CTSD/CTSD-source-evidence.json
CTSD compact source evidence and product scope
PMID:1328388
Role of cathepsin D in antigen presentation of ovalbumin.
PMID:9539769
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation.
PMID:29326245
Fatty acyl recognition and transfer by an integral membrane <i>S</i>-acyltransferase.
file:human/CTSD/CTSD-uniprot.txt
UniProtKB P07339 cathepsin D record