mup-4 (Q21281) review notes

Deep research was skipped: falcon times out in this environment and perplexity-lite is unavailable.
This review relies on cached publications. PMID:25692704 is abstract-only in the cache.

• Single-pass transmembrane receptor with EGF-like repeats, a vWFA domain, two SEA modules and a
  filaggrin-like cytoplasmic domain. It is located at apical hemidesmosomes PMID:11470827.
• Mutants detach the apical epidermis from the cuticle PMID:11470827.
• MUP-4 sequesters STA-2 and releases it when the epidermis is damaged PMID:37759445.
• BLI-1 as the MUP-4 ligand is presumptive PMID:37759445.

Decisions:
- Fibrillin-derived IBAs (ECM structural constituent, extracellular matrix): marked as over-annotated.
MUP-4 is a transmembrane receptor, not a secreted matrix protein.
- Protein binding (IPI with STA-2): MODIFY to GO:0097677 STAT family protein binding.
- NEW terms: GO:0007160 cell-matrix adhesion (comparator: MUA-3 has it by IMP from PMID:11470828),
GO:0098631 cell adhesion mediator activity, and GO:0140311 protein sequestering activity.