Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.
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GADD45B (MyD118) binds to the N-terminal domain of MTK1 MAPKKK
"three related proteins, GADD45alpha (= GADD45), GADD45, (= MyD118), and GADD45gamma, were identified that bound to an N-terminal domain of MTK1"
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GADD45 proteins activate MTK1 kinase activity in vivo and in vitro
"These proteins activated MTK1 kinase activity, both in vivo and in vitro"
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GADD45B gene expression is induced by environmental stresses
"The GADD45-like genes are induced by environmental stresses, including MMS, UV, and gamma irradiation"
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GADD45-like genes induce p38/JNK activation and apoptosis
"Expression of the GADD45-like genes induces p38/JNK activation and apoptosis"
Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding.
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GADD45 proteins are specific activators of MTK1 MAPKKK
"GADD45 proteins (GADD45alpha, beta, and gamma) were identified as MTK1 activators"
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GADD45 proteins bind near the MTK1 inhibitory domain and relieve autoinhibition
"GADD45 proteins bind a site in MTK1 near the inhibitory domain and relieve autoinhibition"
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GADD45 binding eliminates inhibition of the kinase domain
"Binding of GADD45 to the N-terminal region of MTK1 eliminates inhibition of the kinase domain by the autoinhibitory domain"
CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.
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CIN85 enhances MEKK4 activation of MKK6 and p38 following oxidative stress
"CIN85 binding to MEKK4 enhances the activation of MKK6 and of the downstream p38 MAP kinase following oxidative stress and growth factor stimulation"
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CIN85 regulates the activation of MEKK4 by GADD45 proteins
"CIN85 was also shown to regulate the activation of MEKK4 by GADD45 proteins"
Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors.
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GADD45B is a transcriptional target of NF-κB that inhibits the JNK pathway
"we had previously identified the GADD45-family gene, GADD45B, as a transcriptional target of NF-κB encoding a potent and selective inhibitor of the JNK MAPK pathway"
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GADD45B suppresses JNK signaling by blocking MKK7 via direct interaction
"GADD45β suppresses JNK signaling and apoptosis by blocking MKK7 via direct physical interaction"
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GADD45B is highly expressed in multiple myeloma
"GADD45B was markedly upregulated in monoclonal CD138+ PCs from MM patients"
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GADD45β promotes survival of MM cells by inhibiting JNK-mediated apoptosis
"Hence, GADD45β promotes the survival of MM cells by inhibiting JNK-mediated apoptosis"
CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.
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CRIF1 binds specifically to GADD45 family proteins including GADD45B
"CRIF1 binds specifically to the Gadd45 family proteins"
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CRIF1 inhibits Cdc2-cyclin B1 and Cdk2-cyclin E with additive effects with GADD45
"Recombinant CRIF1 inhibits the histone H1 kinase activity of immunoprecipitated Cdc2-cyclin B1 and Cdk2-cyclin E, and the inhibitory effects were additive with Gadd45 proteins"
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.