Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic Gene Ontology annotation based on Rhea mapping

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.

Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.

Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345.

Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.

p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.

Lack of PTEN sequesters CHK1 and initiates genetic instability.

Coupling of human circadian and cell cycles by the timeless protein.

Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones.

14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.

Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function.

Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway.

Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.

The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.

Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation.

Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation.

Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.

Expression of the Bcl-2 protein BAD promotes prostate cancer growth.

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage.

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

Phosphorylation at serine 331 is required for Aurora B activation.

Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling.

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.

ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.

hHR23A is required to control the basal turnover of Chk1.

Architecture of the human interactome defines protein communities and disease networks.

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.

CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

A Proteomic Approach Identifies Isoform-Specific and Nucleotide-Dependent RAS Interactions.

A central chaperone-like role for 14-3-3 proteins in human cells.

Multimodal cell maps as a foundation for structural and functional genomics.

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.

Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.

Recruitment and activation of Chk1

Activation of ATR in response to replication stress

Interaction of other tyrosine kinases with p-KIT

CHEK1 is recruited to resected DNA DSBs

Activation of CHEK1 at resected DNA DSBs

CHEK1 phosphorylates RAD51

CHEK1 phosphorylates BRCA2

CHEK1 phosphorylates TP53

Regulation of TP53 Activity through Phosphorylation

Phosphorylation of CDC25A by CHEK1

Phosphorylation of Cdc25C at Ser 216 by Chk1

Transcriptional Regulation by E2F6

CHEK1 phosphorylates E2F6

CHEK1 phosphorylates NEK11

CHEK1 phosphorylates CHEK2-phosphorylated CDC25A

Falcon deep-research report for human CHEK1 (O14757)