The NEW annotation to GO:0033322 (L-homomethionine biosynthetic process) has been removed, and the
term dropped from core_functions. GO obsoleted the sibling terms GO:0033506 ("glucosinolate
biosynthetic process from homomethionine": "a specific pathway variant, which is out of scope for
GO", replaced by GO:0019761) and GO:0033321 ("homomethionine metabolic process": "an unnecessary
grouping term"). No gene product in any species carries GO:0033322. Read together, this is a GO
convention to annotate the chain-elongation enzymes to glucosinolate biosynthetic process
(GO:0019761), which this gene already carries, not a gap to fill. The question is kept as a
suggested_question for GO.
Re-examined every existing annotation and core against the primary studies and exact GO reactions; preserved all machine-sourced fields and prior rows. Normal fetch-gene and fetch-gene-pmids completed. The default Falcon attempt for this panel (MAM1) failed authentication and perplexity-lite failed insufficient quota; no fabricated provider report was created. Existing provider reports were contextual only; primary sources govern decisions. Plant proteins do not require bacterial fitness fetches.
Correct broad terms now refine to supported descendants. IIL1 and SSU3 catalytic claims refer to heterodimers, with contributes_to in cores; catalytic-site ownership alone does not establish autonomous subunit activity. MAM1 lacks measured IPMS activity, whereas MAM3 retains a weak non-core activity without established native leucine-pathway participation. IMDH1 biochemical comparisons distinguish its specialized methylthioalkylmalate substrate from 3-isopropylmalate; IPMDH2 structural data are not direct IMDH1 structures. BCAT3 terminal transamination is distinct from unelongated methionine transamination and does not establish exclusivity over all chain lengths.
Retained prior NEW process after participation/comparator/ontology/GO-CAM checks. QuickGO queried 2026-10-25: BCAT4 Q9LE06 has one GO:0019761 annotation (PMID:17056707); BCAT6 Q9LPM9 and BCAT3 Q9M401 have none. Comparator absence is recorded, not treated as a gap by itself. Direct BCAT3 recombinant transamination plus native genetics (PMID:18162591) establish catalytic participation. GO:0019761 parents include biosynthesis and sulfur-compound metabolism. Exact accession search in gocams/index.tsv returned no matching models for BCAT3, BCAT4, IIL1, SSU3 or IMDH1. No redundant BP proposal was added.