Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.
A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans.
Functional and biochemical dissection of the structure-specific nuclease ARTEMIS.
Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs.
Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining.
Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair.
XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Activated ATM phosphorylates DCLRE1C
TP53BP1 recruits DCLRE1C to ATM
DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs
PRKDC phosphorylates DCLRE1C at DNA DSBs
POLL or POLM extends aligned DNA DSB ends to fill gaps
DCLRE1C (ARTEMIS) processes DNA DSB ends
Nonhomologous End-Joining (NHEJ)
XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ
TDP1 and TDP2 process unligatable DSB ends
XRCC4:LIG4 ligates DNA DSB ends during NHEJ
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation.
The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair.
DNA-PK autophosphorylation facilitates Artemis endonuclease activity.
The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans.
DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis.
Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair.
Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome.
SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.
Apollo contributes to G overhang maintenance and protects leading-end telomeres.
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.
Defective Artemis causes mild telomere dysfunction.
DNA double-strand break repair pathway choice in Dictyostelium.
Differences in sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient human cells.
Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.
Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast.
Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity.
Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.
The nuclear proteome of Trypanosoma brucei.
Deciphering the interstrand crosslink DNA repair network expressed by Trypanosoma brucei.
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Mutagenesis induced by mono- and bi-functional alkylating agents in yeast mutants sensitive to photo-addition of furocoumarins (pso).