Ankyrin facilitates intracellular trafficking of alpha1-Na+-K+-ATPase in polarized cells.
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Source of the rat alpha1 ER annotation transferred by ISS. Alpha and beta subunits assemble in the ER; alpha1 accumulates in the ER only when ankyrin-dependent export is blocked, so the ER pool is biosynthetic transit, not residence.
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Transport and pharmacological properties of nine different human Na, K-ATPase isozymes.
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Human alpha/beta isozymes expressed in Xenopus oocytes show functional pump currents and isoform-dependent ouabain pharmacology; the protein species and host remain distinct.
"isoform-specific differences exist in the K(+)/ouabain antagonism"
Intersubunit interactions in human X,K-ATPases: role of membrane domains M9 and M10 in the assembly process and association efficiency of human, nongastric H,K-ATPase alpha subunits (ATP1al1) with known beta subunits.
Isoforms of Na+, K+-ATPase in human prostate; specificity of expression and apical membrane polarization.
All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides.
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.
New molecular determinants controlling the accessibility of ouabain to its binding site in human Na,K-ATPase alpha isoforms.
The influence of SRC-family tyrosine kinases on Na,K-ATPase activity in lens epithelium.
Inhibition of Na,K-ATPase-suppressive activity of translationally controlled tumor protein by sorting nexin 6.
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.
The Na,K-ATPase alpha4 isoform from humans has distinct enzymatic properties and is important for sperm motility.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.
Purification of the human alpha2 Isoform of Na,K-ATPase expressed in Pichia pastoris. Stabilization by lipids and FXYD1.
Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis.
Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the plasma membrane of HeLa cells.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation.
Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.
Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1.
Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
FXYD proteins stabilize Na,K-ATPase: amplification of specific phosphatidylserine-protein interactions.
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src.
POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.
ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.
Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1).
Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps.
Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Physical and functional links between anion exchanger-1 and sodium pump.
Identification of a VxP Targeting Signal in the Flagellar Na+ /K+ -ATPase.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states.
Subcellular distribution and immunocytochemical localization of Na,K-ATPase subunit isoforms in human skeletal muscle.
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+
ATP1A:ATP1B:FXYD binds cardiac glycosides
UniProtKB P05023: ATP1A1 (human)
Publisher's Note: ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.