Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Mutations in the fibrinogen aalpha gene account for the majority of cases of congenital afibrinogenemia.
Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival.
Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein.
Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aalpha 9, Leu-->Pro).
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
Fibrinogen and fragment D-induced vascular constriction.
The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance.
Congenital hypofibrinogenemia: characterization of two missense mutations affecting fibrinogen assembly and secretion.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Fibrinogen-induced endothelin-1 production from endothelial cells.
Crystal structure of human fibrinogen.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
The role of fibrin matrices and tissue factor in early-term trophoblast proliferation and spreading.
The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis.
Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Architecture of the human interactome defines protein communities and disease networks.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
MatrisomeDB 2.0: 2023 updates to the ECM-protein knowledge database.
gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors.
Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets.
Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway.
The role of betagamma and alphagamma complexes in the assembly of human fibrinogen.
A mitogenic action for fibrinogen mediated through intercellular adhesion molecule-1.
Crystal structure of fragment double-D from human fibrin with two different bound ligands.
Adhesion of integrin αIIbβ3 to fibrin network
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
n fibrin monomers -> fibrin multimer
fibrin multimer -> fibrin multimer, crosslinked + NH4+
MyD88 forms a complex with TIRAP:activated TLR2/4
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
Multiple IRAK1 autophosphorylation steps
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
Interaction of integrin alphaDbeta2 with fibrin
Interaction of integrin alphaXbeta2 with fibrin
Activated TLR2/4 interacts with MAL (TIRAP)
TIRAP is phosphorylated by BTK
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
Activated TLR2/4:TIRAP interacts with BTK
Translocation of PTK2 to Focal complexes
Autophosphorylation of PTK2 at Y397
Recruitment of GRB2 to p-PTK2
Phosphorylation of pPTK2 by SRC
Interaction of integrin alphaIIb beta3 with Fibrinogen
Interaction of SOS with GRB2 bound to FADK1
Phosphorylation of BCAR1 by SRC-PTK2 complex
Recruitment of BCAR1 to PTK2 complex
Autophosphorylation of SRC
Clustering of Integrin alphaIIb beta3 complexes
Dephosphorylation of inactive SRC by PTPB1
SYK binds to integrin alphaIIb beta3
Exocytosis of platelet alpha granule contents
Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4
Defective MyD88 does not oligomerize within the activated TLR2/4 complex
Defective MyD88 does not bind MAL(TIRAP):TLR2/4
Cleaved fibrinogen products bind TLR4:LY96
FAM20C phosphorylates FAM20C substrates
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
Amyloid fibrils have additional components
Amyloid precursor proteins form ordered fibrils
αIIbβ3:fibrin multimer ->αIIbβ3:fibrin multimer, crosslinked + NH4+
fibrinogen + β-amyloid fibril:Zn2+ -> fibrinogen:β-amyloid fibril:Zn2+
Crystal structure of native chicken fibrinogen at 2.7 A resolution.
Identification and characterization of novel tPA- and plasminogen-binding sites within fibrin(ogen) alpha C-domains.
Structure, stability, and interaction of fibrin αC-domain polymers.
Functional properties of individual sub-domains of the fibrin(ogen) αC-domains.