Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
UniProt entry A0A1J6KPK0 for Nicotiana attenuata FOX1_2
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FOX1_2 is a BBL-family late oxidase associated with nicotine biosynthesis
"Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine ... Catalyzes a late oxidation step subsequent to the pyridine ring condensation reaction in the biosynthesis of alkaloids."
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UniProt assigns FOX1_2 to vacuole and FAD-dependent chemistry
"CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000256|ARBA:ARBA00004116}."
NaBBL2 FOX1_2 candidate notes
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The glucosylation paper mechanistically secures BBL-family late-pathway chemistry
"The full preprint makes BBLa/NicGS a mechanistically defined late-pathway enzyme that drives stereoselective nicotine formation, with both structural and dropout support."
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FOX1_2 is the best current BBL2-like anchor in the project
"That strengthens the existing choice to keep FOX1_2 as the best current BBL2-like anchor, while still leaving exact NICAT BBL paralog resolution open."