PANTHER family review PTHR45803: IBA propagation assessment for ste11
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs.
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Ste11 recognizes an extended ~12-bp minor-groove motif and bends DNA upon binding via its HMG box.
"By site selection, we identify a highly specific 12-base pair motif for Ste11, AGAACAAAGAAA."
Dmc1 of Schizosaccharomyces pombe plays a role in meiotic recombination.
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The meiotic dmc1/rad24 bicistronic transcript is induced under Ste11 control, illustrating Ste11 regulation of meiotic recombination genes.
"Induction of the bicistronic transcript is under the control of a meiosis-specific transcription factor, Ste11."
A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development.
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ste11 transcription is induced by starvation/low PKA via the zinc-finger activator Rst2 and is positively autoregulated through a TR-box in its own promoter.
"A complete Ste11p-binding motif (TR box) found in the promoter region was necessary for the full expression of ste11, suggesting that Ste11p is involved in the activation of ste11."
The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating.
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rgs1 is a direct Ste11 target gene required for mating.
"rgs1, a member of the Regulator of G-protein Signalling (RGS) family, as a novel Ste11 target gene."
Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction.
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Study of the fission-yeast pheromone signaling pathway controlling mat1-Pm transcription and meiotic entry. The cached abstract foregrounds the upstream kinase ste8 (= byr2); PomBase used this paper as the IMP source for ste11's positive regulation of Pol II transcription (ste11 is the master activator in this pathway). Full text is not in our cache.
"the mat1-Pm gene, which is required for entry into meiosis, is expressed in response to a pheromone signal"
Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.
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Ste11 is a direct target of the pheromone-pathway MAPK Spk1 (physical interaction and in vitro phosphorylation) and of the Pat1 kinase; ste11 is required for pheromone-induced G1 arrest.
"we show that Spk1 can interact physically with Ste11 and also phosphorylate the transcription factor in vitro."
Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.
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Ste11 is an HMG-box transcription factor essential for sexual development; it binds the TR-box (TTCTTTGTTY) and positively regulates mating-type and mei2 gene transcription.
"Expression of ste11 is essential for induction of sexual development, and its ectopic expression stimulates uncontrolled mating and sporulation."
ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Fission yeast Tor2 promotes cell growth and represses cell differentiation.
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Tor2 (TORC1) represses sexual differentiation by interfering with Ste11 and Mei2, defining the Tor2-Mei2-Ste11 regulatory association.
"This newly revealed function of Tor2 appears to operate by interfering with the functions of the transcription factor Ste11 and the meiosis-promoting RNA-binding protein Mei2."
TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.
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PKA and TOR pathways repress Ste11 by blocking its nuclear accumulation; Ste11 shuttles between cytoplasm and nucleus and accumulates in the nucleus under starvation.
"both the PKA and the TOR pathways inhibit Ste11 nuclear accumulation to repress Ste11-dependent gene expression."
Multistep regulation of protein kinase A in its localization, phosphorylation and binding with a regulatory subunit in fission yeast.
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In PKA-null (sam) mutants Ste11 is induced and localizes to the nucleus even in rich medium, confirming PKA-dependent control of Ste11.
"Rst2 and Ste11 proteins were induced and localized to the nucleus of sam5 and sam7 mutants even under rich glucose conditions"
A dominant negative 14-3-3 mutant in Schizosaccharomyces pombe distinguishes the binding proteins involved in sexual differentiation and check point.
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Ste11 is among the 14-3-3-related sexual-differentiation factors; it is active in the nucleoplasm.
"A dominant negative 14-3-3 mutant in Schizosaccharomyces pombe distinguishes the binding proteins involved in sexual differentiation and check point."
A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
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Genome-wide atlas confirms Ste11 physical interactions with chromatin at RNA polymerase II cis-regulatory regions.
"A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin."
Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.
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mat1-Pm induction requires a TR-box recognized by Ste11; ste11 deletion abolishes and Ste11 overexpression boosts mat1-Pm expression.
"Almost no expression of mat1-Pm was detected in a ste11 deletion mutant, whereas overproduction of Ste11 greatly increased the expression."
Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3.
Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase.
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Ste11 is a substrate of the meiosis-repressing Pat1/Ran1 kinase, a reaction inhibited by the Mei3 pseudosubstrate.
"the ste11+ transcription factor is a substrate for ran1+ in vitro and that this reaction is directly inhibited by mei3+."
Cell differentiation by interaction of two HMG-box proteins: Mat1-Mc activates M cell-specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites.
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Mat1-Mc cooperates with Ste11, enhancing Ste11 binding to weak M-cell TR-boxes and forming a Ste11-Mat1-Mc-DNA complex for M-specific activation.
"The Mat1-Mc protein caused a dramatic increase in the DNA-binding of Ste11 to this box"