Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

UniProt entry for human SOX9

Sex reversal by loss of the C-terminal transactivation domain of human SOX9.

Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer.

RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition.

A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversal.

Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester.

Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.

Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells.

SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation.

The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template.

SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium.

Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity.

Generation of transgenic mice for conditional overexpression of Sox9.

Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription.

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.

Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells.

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations.

An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer.

Inhibitory role of Notch1 in calcific aortic valve disease.

miR-1247 functions by targeting cartilage transcription factor SOX9.

The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.

Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification.

The microRNA-29 family in cartilage homeostasis and osteoarthritis.

Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia.

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs).

The SOXE transcription factors-SOX8, SOX9 and SOX10-share a bi-partite transactivation mechanism.

Reactome pathway reference

Reactome pathway reference

Deep research report on SOX9