Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry for pqqA (Q49148, Coenzyme PQQ synthesis protein A)
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"Required for coenzyme pyrroloquinoline quinone (PQQ)"
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"Pyrroloquinoline quinone (Glu-Tyr)"
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"Belongs to the PqqA family"
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"There seems to be another source for PQQ in this"
QuickGO GOA annotations for pqqA (Q49148)
Falcon (Edison Scientific) deep-research report for pqqA (Q49148), Methylorubrum extorquens AM1
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"PqqA as a short peptide precursor"
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"ribosomally synthesized precursor peptide"
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"substrate peptide for the first committed PQQ-biosynthetic transformation"
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"The peptide itself does **not catalyze a reaction**; it is the biosynthetic substrate."
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"conserved **Glu** and **Tyr** residues that furnish atoms to the PQQ core"
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"one glutamate and one tyrosine in PqqA are essential for PQQ formation"
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"biosynthetic function of PqqA is intracellular"
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"mature **PQQ** then serves as a redox cofactor for **periplasmic methanol dehydrogenases** such as MxaFI/XoxF"
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"Q49148 should be interpreted as the **precursor-peptide locus**"
pqqA is not required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1.
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"both deletion and insertion mutants of pqqA in M. extorquens AM1 grow normally"
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"pqqA, has been proposed to encode a peptide precursor of PQQ"
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"a different peptide in M. extorquens AM1 can substitute for PqqA"