GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

PMID:8892827

Characterization of the helper proteins for the assembly of tail fibers of coliphages T4 and lambda.

T4 helper protein p57 (gp57A) is a highly alpha-helical (~80% alpha-helix) nonstructural chaperone required for the assembly of p12 (short tail fiber), p34 (proximal long tail fiber), and—together with p38—p37 (distal long tail fiber).

"In the absence of the other, p57, p34 (another component of the long tail fiber), p37, and p12 (the subunit of the short tail fiber) remain unassembled."

file:BPT4/57/57-uniprot.txt

UniProtKB record for gp57A (P04532)

gp57A is a chaperone essential for the folding and oligomerization of both the short and long tail fibers of bacteriophage T4.

"Chaperone essential for folding and oligomerization of both"

file:BPT4/57/57-deep-research-falcon.md

Deep research review for bacteriophage T4 gene 57 (gp57A)

gp57A is a small nonstructural molecular chaperone acting in the host cell cytoplasm to promote trimeric folding and assembly of gp12, gp34, and gp37 without being incorporated into the mature virion.

"Gene **57** of *Enterobacteria phage T4* encodes **gp57A** (historically also called gp57 or p57), a **small, nonstructural assembly helper/molecular chaperone** that is **required for correct assembly/folding of tail fiber components**—most consistently **gp12 (short tail fiber)** and **gp34 and gp37 (long tail fiber components)**—but is **not incorporated into the mature virion**."