GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

PMID:37248218

LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila models.

Rubicon (RNAi, frameshift alleles, glial tsKO) is required in glia for degradation of engulfed axon debris and phagosome-lysosome fusion; overexpression accelerates clearance.
Glial Rubicon::mRFP localizes to Rab7-positive late endosomes/phagosomes and to debris-containing LAPosomes, rarely to Rab5 early endosomes.

PMID:30783089

Suppression of autophagic activity by Rubicon is a signature of aging.

dRubicon rises with age; knockdown increases brain autophagosome/autolysosome pools, extends female lifespan (most efficiently from neurons) and reduces polyQ toxicity.

PMID:34189208

Dataset on the effect of Rubicon overexpression on polyglutamine-induced locomotor dysfunction in Drosophila.

Fly and human Rubicon share the N-terminal RUN and C-terminal zinc-finger (RH) regions; overexpression of WT or delta-RUN dRubicon was assessed for effects on polyQ toxicity.

PMID:38977659

Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization.

Maternal Rubicon on the limiting membrane of egg MVBs is required for PtdIns(3)P production, Atg8a recruitment and degradation of the sperm mitochondrial derivative.

file:DROME/Rubicon/Rubicon-uniprot.txt

UniProtKB Q9W3C9 record for Drosophila Rubicon

file:human/RUBCN/RUBCN-uniprot.txt

UniProtKB Q92622 record for human RUBCN

file:DROME/Rubicon/Rubicon-notes.md

Rubicon review notes

file:worm/Y56A3A.16/Y56A3A.16-bioinformatics/RESULTS.md

Domain architecture comparison of Rubicon family members (RUBCN, RUBCNL, fly Rubicon, worm Y56A3A.16)