Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
UniProt entry for TOLL9 (AGAP006974-PA)
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Toll-family architecture includes LRRs, a membrane segment at 607–631 and TIR domain at 667–807.
"Belongs to the Toll-like receptor family."
Deep research report on TOLL9 function
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TOLL9 belongs to conserved Toll subfamily with species-specific ectodomain divergence
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TIR domain phylogeny supports conserved signaling despite ectodomain variation
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Functional pathway inferred from domain architecture and comparative genomics
OpenScientist report on TOLL9 ligand and immune-pathway specificity
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A focused independent report supports retaining generic Toll receptor assertions while treating Anopheles-specific PRR and Toll-immune pathway assignments as unproven leads.
"no TOLL9 ligand, interaction, or loss-of-function phenotype has been demonstrated."
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OpenScientist recommended retaining generic Toll receptor annotations while treating pattern-recognition receptor and Toll-pathway immune terms as unasserted leads for TOLL9.
"The evidence does not justify promoting TOLL9 from a **generic signaling receptor** to a **specific microbial-PAMP pattern-recognition receptor** at the species level."
mosGILT controls innate immunity and germ cell development in Anopheles gambiae.
Toll9 from Bombyx mori functions as a pattern recognition receptor that shares features with Toll-like receptor 4 from mammals.
Lack of an antibacterial response defect in Drosophila Toll-9 mutant.
TOLL9 re-review with live ontology constraint and exact PAINT lineage
TOLL9 ontology constraints and PAINT lineage snapshot