Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

Electronic Gene Ontology annotations created by ARBA machine learning models

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

Combined Automated Annotation using Multiple IEA Methods

CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.

Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output.

2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48.

Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48.

Mutational analysis of the human 2B4 (CD244)/CD48 interaction: Lys68 and Glu70 in the V domain of 2B4 are critical for CD48 binding and functional activation of NK cells.

Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: a role for lipid rafts in T cell activation.

Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.

UniProt entry P18181 (CD48_MOUSE)

2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells.

2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice.

Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1.

Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition.

2B4 inhibits NK-cell fratricide.

Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.

OpenScientist hypothesis report: mouse CD48 and natural killer cell activation direction