Falcon deep research report for SPARC
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Falcon supports SPARC as a secreted matricellular ECM glycoprotein whose core molecular functions are collagen/ECM binding, calcium-associated matrix organization, and regulation of cell-ECM interactions.
"SPARC is a **secreted, extracellular matrix (ECM)-associated "matricellular" glycoprotein** that modulates cell-ECM interactions and ECM remodeling rather than serving as a bulk structural ECM component."
Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth.
Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesis.
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
Spreading of embryologically distinct urothelial cells is inhibited by SPARC.
Localization of platelet osteonectin at the internal face of the alpha-granule membranes in platelets and megakaryocytes.
Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen.
Structural basis of sequence-specific collagen recognition by SPARC.
Interaction of recombinant myocilin with the matricellular protein SPARC: functional implications.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane.
Complex formation of human thrombospondin with osteonectin.
Osteonectin, a bone-specific protein linking mineral to collagen.
Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin.
STAB1 (FEEL-1) binds ligands
STAB1:ligand is endocytosed
SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+
Exocytosis of platelet alpha granule contents
SPARC gene transcription is stimulated by ERBB4s80