IFT88 notes

Deep research: not run. In this environment falcon times out after 600 s and perplexity-lite is not
installed. The review uses the cached GOA-cited publications, two extra cached papers
(PMID:11062270, PMID:14603322) and the UniProt record.

Key points

• Core IFT-B1 subunit. PMID:11062270
• Required for cilium assembly. PMID:11062270
• Pre-docks at the ciliary base and is released into the cilium by CEP19-RABL2. PMID:28625565
• Mouse polaris/Ift88 is needed for Hedgehog signalling. PMID:14603322

Curation decisions

• REMOVE: IFT-A (GO:0030991) IDA from PMID:26980730. IFT88 is a canonical IFT-B subunit, and the
  same paper supports the retained IFT-B annotation. This looks like a wrong-complex term choice.
• REMOVE: response to silicon dioxide (a rat expression IEA) and all generic protein binding rows.
• MODIFY: positive regulation / regulation of cilium assembly changed to cilium assembly (IFT88 is part of the machinery, not a regulator).
• Reactome aggrephagy "cytosol" rows list IFT88 as a misfolded ciliary-protein substrate. They are kept as non-core.
• Core MF: contributes_to GO:0140597 (the GO label is now "protein carrier chaperone"), in IFT-B. No better
  single-subunit MF term exists for an IFT-B scaffold.