LUX (PCL1, At3g46640; UniProt Q9SNB4) curation notes

2026-10-06: initial review (module plant_circadian_clock_oscillator)

• Fetched with just fetch-gene ARATH Q9SNB4 --alias LUX. Falcon deep research failed; review based on cached publications.

Key findings

• GARP/MYB DNA-binding protein essential for the clock PMID:16164597; lux mutants lose rhythm robustness in LL/DD PMID:16006522.
• Direct repression of PRR9 and negative autoregulation PMID:21236673.
• DNA-binding subunit of the EC PMID:21753751; LBS consensus GAT(A/T)CG, with a crystal structure of the MYB domain bound to DNA PMID:32165537.
• EC binding is temperature-dependent PMID:28650433.

Decisions

• DNA-binding TF activity (IBA/IEA/ISS): MODIFY to GO:0001227 (repressor), keeping all three rows consistent.
• Positive regulation of circadian rhythm IMP (UniProt): KEEP_AS_NON_CORE; better captured as an oscillator component.
• Regulation of gene expression IMP (RVE8 paper): KEEP_AS_NON_CORE (indirect).