Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
A protein factor essential for microtubule assembly.
Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.
Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments.
Tau promoter confers neuronal specificity and binds Sp1 and AP-2.
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor neurite formation.
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.
Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain.
The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.
Surface-decoration of microtubules by human tau.
Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation.
Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation.
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays.
Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease.
Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model.
14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.
Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells.
Akt and CHIP coregulate tau degradation through coordinated interactions.
Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.
Effect of phosphorylation on interaction of human tau protein with 14-3-3zeta.
Fluorescence microscopy and 3D image reconstruction of cytokine initiated disruption of the Parkinson disease associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells.
Tau protein binds to microtubules through a flexible array of distributed weak sites.
Tau--an inhibitor of deacetylase HDAC6 function.
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.
Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta.
A role for FKBP52 in Tau protein function.
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.
Nuclear tau, a key player in neuronal DNA protection.
Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau.
Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage.
Tau promotes neurodegeneration via DRP1 mislocalization in vivo.
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.
Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites.
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.
Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains.
Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.
Impact of the cellular prion protein on amyloid-β and 3PO-tau processing.
Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease.
Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.
AlphaScreen HTS and live-cell bioluminescence resonance energy transfer (BRET) assays for identification of Tau-Fyn SH3 interaction inhibitors for Alzheimer disease.
A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.
A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology.
LRRK2 Promotes Tau Accumulation, Aggregation and Release.
The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy.
Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain.
Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.
Regulation of Microtubule Assembly by Tau and not by Pin1.
FRMD4A-cytohesin signaling modulates the cellular release of tau.
Tau physiology and pathomechanisms in frontotemporal lobar degeneration.
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice.
Roles of tau protein in health and disease.
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.
Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain.
The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein.
Structures of filaments from Pick's disease reveal a novel tau protein fold.
Role of tau N-terminal motif in the secretion of human tau by End Binding proteins.
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C.
GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease.
A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.
ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation.
Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.
Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.
Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain.
Tau is enriched on dynamic microtubules in the distal region of growing axons.
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau.
Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis.
Tau interacts with src-family non-receptor tyrosine kinases.
Caspase-mediated cleavage of Tau
p-PKR dimer phosphorylates MAPT
AMPK-negatively regulates binding of MAPT to microtubules
UniProt text export for MAPT (P10636)