Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans.
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DAF-19 is an RFX-type transcription factor expressed in all ciliated sensory neurons
"We report that the C. elegans gene daf-19 encodes an RFX-type transcription factor that is expressed specifically in all ciliated sensory neurons."
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Loss of daf-19 causes absence of cilia
"Loss of daf-19 function causes the absence of cilia, resulting in severe sensory defects."
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DAF-19 activates expression of shared ciliary components via RFX target sites
"Several genes that function in all ciliated sensory neurons have an RFX target site in their promoters and require daf-19 function"
The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms.
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osm-5 expression is regulated by DAF-19
"osm-5 is expressed in ciliated sensory neurons in C. elegans and its expression is regulated by DAF-19, an RFX-type transcription factor that governs the expression of other genes involved in cilia formation in the worm."
Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior.
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DAF-19 is the ciliogenic pathway regulator
"The ciliogenic pathway regulator DAF-19 affects downstream components of the HOB-specific program indirectly and is independent of EGL-46 activity."
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DAF-19 regulates a general ciliogenic program distinct from cell-type-specific pathways
"This EGL-46- regulated program is specific to HOB and is distinct from a general ciliogenic pathway functioning in all ciliated neurons"
Distinct isoforms of the RFX transcription factor DAF-19 regulate ciliogenesis and maintenance of synaptic activity.
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DAF-19C specifically expressed in ciliated sensory neurons
"The short isoform DAF-19C is specifically expressed in ciliated sensory neurons and sufficient to rescue all cilia-related phenotypes of daf-19 mutants."
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DAF-19A/B function in nonciliated neurons for synaptic maintenance
"In contrast, the long isoforms DAF-19A/B function in basically all nonciliated neurons."
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daf-19 mutants lack cilia on 60 sensory neurons
"In the worm Caenorhabditis elegans, lack of the RFX transcription factor DAF-19 leads to the absence of cilia normally found on 60 sensory neurons."
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daf-19 mutants have synaptic maintenance phenotypes
"We discovered behavioral and cellular phenotypes in daf-19 mutants that depend on the isoforms daf-19a/b. These novel synaptic maintenance phenotypes are reminiscent of synaptic decline seen in many human neurodegenerative disorders."
Functional specialization of sensory cilia by an RFX transcription factor isoform.
RFX transcription factor DAF-19 regulates 5-HT and innate immune responses to pathogenic bacteria in Caenorhabditis elegans.
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DAF-19 regulates tph-1 expression in ADF neurons
"daf-19 is required for tph-1 expression in the ADF neurons."
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DAF-19 works with ATF-7 to regulate immune genes
"We show that DAF-19 concerts with ATF-7, a member of the activating transcription factor (ATF)/cAMP response element-binding B (CREB) family of transcription factors, to regulate tph-1 and antimicrobial genes, reminiscent of RFX-CREB interaction in human immune cells."
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daf-19 mutants have heightened susceptibility to PA14
"daf-19 mutants display heightened susceptibility to killing by PA14."
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DAF-19 suppresses hyperactive TIR-1 immunity
"A forward genetic screen for suppressors of the hyperactive TIR-1 led to the identification of DAF-19, an ortholog of regulatory factor X (RFX) transcription factors that are required for human adaptive immunity."
TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.
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DAF-19 positively regulates transcription of ciliary transition zone genes
"Mechanistic studies in Caenorhabditis elegans showed that TMEM-107 controls ciliary composition and functions redundantly with NPHP-4 to regulate cilium integrity, TZ docking and assembly of membrane to microtubule Y-link connectors."
Deep research report on daf-19