Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Combined Automated Annotation using Multiple IEA Methods

A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.

The N-terminal half-domain of the long form of tRNase Z is required for the RNase 65 activity.

Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the transfer ribonuclease Z cleavage site, processing kinetics, and substrate secondary structure.

Functional analyses for tRNase Z variants: an aspartate and a histidine in the active site are essential for the catalytic activity.

Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation.

Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs.

RNA processing in human mitochondria.

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Structural basis of 3'-tRNA maturation by the human mitochondrial RNase Z complex.

ELAC2 cleaves the 3' end of pre-tRNA

Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript

Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript

tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis

ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)

ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy.

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs).