lpxC (PA4406, P47205) review notes

Review session 2026-11-05 (PseudoCAP IBA-seed protocol, tier 2)

Fetched with just fetch-gene PSEAE P47205 --alias lpxC; accession matches the worklist. No
deep-research provider used. PMID:9068651 is abstract-only: PubMed MCP returned no body and Europe
PMC has no full-text XML for PMC178929.

Literature

PMID:9068651
Recombinant P. aeruginosa LpxC is soluble, EDTA-sensitive and reactivated by metal. UniProt cites
the paper (ECO:0000269) for function, catalytic activity and Zn cofactor.

Annotation decisions

All 7 rows ACCEPT (GO:0103117 x3, GO:0009245 x3, GO:0005737 IBA). No source defects.

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN002134692	GO:0009245 lipid A biosynthetic process	2	79 (62 taxa)	GO:0009245, IDA, PMID:9068651 (PseudoCAP)	SOUND	The abstract states the enzyme was expressed, assayed and purified; LpxC performs the committed step of lipid A synthesis.	E. coli LpxC P0A725	Yes (E. coli LpxC has extensive experimental support)

The plant and Aquifex seeds of the node's GO:0103117 and GO:0005737 IBDs do not affect this gene.