Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation.
The lncRNA CTD-2256P15.2 (MARCHF6-DT) encodes the micropeptide PACMP, which maintains CtIP abundance by blocking CtIP-KLHL15 association and binds damage-induced PAR to enhance PARP1-dependent PARylation.
"PACMP not only prevents CtIP from ubiquitination through inhibiting the CtIP-KLHL15 association but also directly binds DNA damage-induced poly(ADP-ribose) chains to enhance PARP1-dependent poly(ADP-ribosyl)ation"