Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2.

Molecular mechanisms of autosomal recessive hypercholesterolemia.

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery.

Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1.

Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein.

The adaptor protein ARH escorts megalin to and through endosomes.

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits.

Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein.

Towards a proteome-scale map of the human protein-protein interaction network.

Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions.

A proteome-scale map of the human interactome network.

Widespread macromolecular interaction perturbations in human genetic disorders.

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.

Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.

Architecture of the human interactome defines protein communities and disease networks.

A reference map of the human binary protein interactome.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

A comprehensive two-hybrid analysis to explore the Legionella pneumophila effector-effector interactome.

LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D

LDLR is bound by DAB2 and ARH

F- and N- BAR domain proteins bind the clathrin-coated pit

CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

Clathrin recruits PIK3C2A

Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2

SNX9 recruits components of the actin polymerizing machinery

BAR domain proteins recruit dynamin

SYNJ hydrolyze PI(4,5)P2 to PI(4)P

Endophilins recruit synaptojanins to the clathrin-coated pit

HSPA8-mediated ATP hydrolysis promotes vesicle uncoating

Clathrin recruits auxilins to the clathrin-coated vesicle

Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle

Dynamin-mediated GTP hydrolysis promotes vesicle scission

Dissociation of clathrin-associated proteins

Dissociation of AAK1 and dephosphorylation of AP-2 mu2

RAB5 and GAPVD1 bind AP-2

LRP2-mediated TCN2:RCbl uptake and delivery to lysosome

LRP2 binds extracellular TCN2:RCbl