Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Towards a proteome-scale map of the human protein-protein interaction network.
Defining human ERAD networks through an integrative mapping strategy.
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
The ER membrane protein complex is a transmembrane domain insertase.
The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.
EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.
A reference map of the human binary protein interactome.
Structural basis for membrane insertion by the human ER membrane protein complex.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
The architecture of EMC reveals a path for membrane protein insertion.
Expanding EMC foldopathies, topogenesis deficits alter the neural crest.
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Damaging EMC9 (and EMC10) variants are reported in 18 individuals from 10 families with congenital anomalies; CRISPR depletion of emc9 in Xenopus tropicalis reduced neural crest marker (sox10) expression and produced craniofacial and neuromuscular phenotypes, and decreased the WNT receptor Fzd7 with marked reduction of nuclear beta-catenin, implicating EMC9 in membrane-protein topogenesis required for WNT-dependent development.
Squaring the EMC - how promoting membrane protein biogenesis impacts cellular functions and organismal homeostasis.
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Review placing EMC2, EMC8, and EMC9 as the cytosolic (non-transmembrane, peripheral) subunits forming the cytoplasmic interface of the ER-resident EMC; EMC9 (~208 aa) is classified among peripheral, non-core subunits.
The Function, Structure, and Origins of the ER Membrane Protein Complex.
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Authoritative review placing EMC2, EMC8, and EMC9 as cytosolic subunits, with the EMC8/EMC9-containing cytosolic cradle likely engaging membrane-protein clients before insertion/folding.
EMC chaperone-Ca(V) structure reveals an ion channel assembly intermediate.