GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000041
Gene Ontology annotation based on UniPathway vocabulary mapping
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10806195
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
PMID:11514595
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.
PMID:15062544
Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions.
PMID:15210697
NADPH oxidase-dependent acid production in airway epithelial cells.
PMID:15972824
Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.
PMID:16111680
Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.
PMID:19339556
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
PMID:19386603
ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli.
PMID:19460756
Caenorhabditis elegans and human dual oxidase 1 (DUOX1) "peroxidase" domains: insights into heme binding and catalytic activity.
PMID:22814254
The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.
PMID:25761904
When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.
PMID:33420071
Structures of human dual oxidase 1 complex in low-calcium and high-calcium states.
PMID:34168077
Dual oxidase 1 promotes antiviral innate immunity.
PMID:34784249
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca(2+) signaling during T cell activation.
PMID:39126279
The NADPH oxidases DUOX1 and DUOX2 are sorted to the apical plasma membrane in epithelial cells via their respective maturation factors DUOXA1 and DUOXA2.
Reactome:R-HSA-209815
Tyrosine is monoiodinated
Reactome:R-HSA-209840
Two DITs combine to form thyroxine
Reactome:R-HSA-209925
DIT and MIT combine to form triiodothyronine
Reactome:R-HSA-209973
Tyrosine is diiodinated
Reactome:R-HSA-350901
Iodide is organified
Reactome:R-HSA-5693681
DUOX1 reduces O2 to H2O2