Official human FOXE3 is HGNC:3808 / UniProtKB:Q13461, a 319-aa forkhead transcription factor. The current reviewed record has no alternative-product declaration. The genuine import retained 42 original QuickGO contexts as 42 exported rows and 42 distinct seed annotations. Original qualifiers, evidence codes, references and donor groups are preserved; there are no NOT assertions or annotation extensions.
The accepted source-specific proposal contains 12 ACCEPT, 16 KEEP_AS_NON_CORE, 11 TOO_GENERAL and 3 UNDECIDED decisions. One core describes Pol II transcription-factor activity in nuclear/chromatin contexts and lens development. No NEW annotations, additional natural products or publication quotations are proposed.
Human FOXE3 chromatin occupancy and DNAJB1 promoter/RNA responses support transcriptional regulation. Mouse fragment-binding and lens genetics supply complementary evidence with their species and construct limits retained. DNAJB1 depletion and zebrafish dnajb1 rescue are downstream-gene experiments, not FOXE3 perturbation or rescue. The discovery-screen direction inconsistency is distinguished from the independent reporter/qPCR evidence.
Selected original text was inspected for five papers; three sources remain limited to abstract/preview or supplement descriptions. The unresolved original human assay attribution of PMID:10652278 remains separate from its positive mouse lens genetics. The inaccessible assays in PMID:22527307, PMID:25504734 and PMID:8825632 are not newly certified by independent gene-level support. Raw 22, 25 and 41 remain undecided for apoptosis, cell-cycle specificity and transcription-complex membership. The descriptions in the source guide retain all source-specific limits.
The six IBA contexts have target-specific tree, MSA and literal IBD grounding, including the exact 319-aa target sequence and descent from positive PTN000930906. Seventeen human transfer contexts retain their mouse provenance and complete captured donor objects. Mixed part_of/is_a developmental paths are not described as pure subclass paths. Historical mouse proteins, fragments and disease variants are not additional human products.
The original UniProt REST service initially returned HTTP500. Its subsequent complete native response matched the verified human identity, sequence and PTHR11829 family. The unmodified gene fetcher then completed successfully. Eight publication caches were acquired: three carry full text and five contain abstracts. Three existing family files were preserved exactly. Source availability is recorded separately from actual primary-reading scope in the evidence map. The untouched PENDING seed and exact raw/exported/stored join are retained as provenance.
No FOXE3 provider job was attempted because the inherited Falcon/perplexity credential failure remained unresolved. The accepted manual primary research supplies the evidence; no provider output was fabricated. This authored candidate has not yet undergone validation, status computation, history creation or rendering. Only actual outcomes will be appended after those steps run.
Source guide · Source evidence
The default gene validation, including term checks, passed with no curation advisories. Strict GOA validation confirmed all 42 existing annotations match the genuine export. The computed status is COMPLETE; the three source-specific UNDECIDED decisions remain unchanged. The initial status audit reported the provisional DRAFT value as a mismatch because it only automatically fills an absent status. Applying the computed value resolved that mismatch without changing the science.
Exact conservation checks preserved all 42 original contexts and seed machine dictionaries, all accepted decisions, the 14 fetched reference identities and titles, and all 11 normal-source files. The review has one core function and no NEW annotations, publication quotations, alternative products or extension atoms. A genuine CREATE history record was scaffolded and validated. Private rendering and link inspection confirmed 42 annotation rows, one core, 14 references, all eight original-study URLs and the local notes/source-guide/evidence links. The dependency's pkg_resources deprecation notice is separate from the zero curation advisories. No provider job, broad corpus validation or new environment was used.
The update refines the two broad transcription-process contexts to positive Pol II regulation of the tested DNAJB1 target, makes the five existing lens epithelial proliferation/fiber-differentiation contexts part of the developmental core, and retains the reported human G1-arrest context as non-core with its original access limits. The general Pol II regulatory IBA is retained as TOO_GENERAL relative to an independently supported positive child; no positive direction is inferred at the PAINT node. The original 42 contexts, their machine fields, all 11 source files and the original history remain unchanged. There are no NEW annotations, products or publication quotations.
The source guide explains the selected browser-extracted originals, failed separate binary downloads, reference-verification scope and official PMID:8825632 DOI/PII. The evidence record retains the full original context objects and joins. The initial published validation results above remain historical. The amended review passed default validation, including ontology and markdown-reference checks, with zero curation advisories; strict GOA validation matched all 42 stored annotations and computed status remained COMPLETE. Conservation checks confirmed all original machine fields, raw context objects and source files, the approved review/core changes, the prior notes prefix and the original history. The new EDIT history passed validation. Private rendering and link inspection confirmed 42 annotation rows, one core, 14 references, nine original-study/DOI links and local documentation links. The dependency deprecation notice is separate from curation advisories. No provider job, source acquisition or broad corpus validation was run for this amendment.