Use of the ND evidence code for Gene Ontology (GO) terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A family of tetraspans organizes cargo for sorting into multivesicular bodies.
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The Cos proteins are a family of highly ubiquitinated tetraspan yeast membrane proteins that cluster into endosomal subdomains, concentrate ubiquitinated and GPI-anchored cargo, and are required for efficient sorting of that cargo into MVB intralumenal vesicles along the ESCRT- and ubiquitin-dependent pathway.
"Here we show that a family of highly ubiquitinated tetraspan Cos proteins provides a Ub signal in trans, allowing sorting of nonubiquitinated MVB cargo into the canonical ESCRT- and Ub-dependent pathway."
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COS gene expression is induced by nutrient stress through an NAD+/Sir2-dependent mechanism (relief of subtelomeric silencing), accelerating downregulation of cell surface proteins.
"Expression of these proteins increases during nutrient stress through an NAD(+)/Sir2-dependent mechanism that in turn accelerates the downregulation of a broad range of cell-surface proteins."