Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
RGD ISO annotations to rat from other mammalian species
The apical localization of SGLT1 glucose transporter is determined by the short amino acid sequence in its N-terminal domain.
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N-terminal domain (first 19 amino acids) determines apical localization in MDCK cells
"The products of N-terminal deletion clones up to the 19th amino acid were localized at the apical plasma membrane, whereas the products of N-terminal 20- and 23-amino-acid deletion clones were localized along the entire plasma membrane."
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D28 mutations cause cytoplasmic retention
"The products of D28N and D28G clones were localized in the cytoplasm, showing that the aspartic acid-28 may be essential for the delivery of SGLT1 to the plasma membrane."
Localization of the Na+-D-glucose cotransporter SGLT1 in the blood-brain barrier.
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SGLT1 located in luminal membrane of brain capillary endothelial cells
"Immunostaining suggested that SGLT1 is located in the luminal membrane of the endothelial cells and in intracellular vesicles."
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Also found in intracellular vesicles
"Immunostaining suggested that SGLT1 is located in the luminal membrane of the endothelial cells and in intracellular vesicles."
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SGLT1 mRNA upregulated after brain ischemia
"1 day after a transient occlusion of the right middle cerebral artery, SGLT1 mRNA was detected in capillaries of both brain hemispheres."
The endogenous CXXC motif governs the cadmium sensitivity of the renal Na+/glucose co-transporter.
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SGLT1 is a target for Cd2+ toxicity via CXXC motif
"the renal brush-border membrane Na+/glucose co-transporter-1 (SGLT1) is a molecular target for Cd2+ toxicity"
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Demonstrated Na+/glucose cotransport activity
"Cd2+ acted as a noncompetitive, partial inhibitor of methyl-D-glucopyranoside uptake in vesicles from COS-7 cells transiently expressing SGLT1"
Rat renal glucose transporter SGLT1 exhibits zonal distribution and androgen-dependent gender differences.
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SGLT1 localized to S3 segment of proximal tubule
"the expression of SGLT1 is represented by a 75-kDa protein localized largely in the PT S3 segments"
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Gender differences in expression (female > male)
"In tissue cryosections, the antibody strongly stained BBM of the S3 PT segments in the OS and medullary rays (F > M)"
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Androgen-dependent regulation
"castration upregulated, whereas treatment of castrated rats with testosterone, but not with estradiol or progesterone, downregulated the 75-kDa protein"
Asymmetric subcellular distribution of glucose transporters in the endothelium of small contractile arteries.
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SGLT1 present in vascular endothelium
"We identified GLUT-1 to -5 and SGLT-1 in the endothelial cells of all three vascular beds."
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Clusters at cell-cell junctions
"Clusters of the glucose transporter isoforms were found at a high density in proximity to the cell-to-cell junctions."
Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption.
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SGLT1 at brush border membrane of jejunum
"Western blotting showed that in each case there was a significant decrease in apical GLUT2 level, but no change in SGLT1 level."
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SGLT1 transport initiates GLUT2 insertion
"We have proposed a model of intestinal glucose absorption in which transport by SGLT1 induces rapid insertion and activation of GLUT2 in the apical membrane"
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SGLT1 component is phloretin-insensitive
"the phloretin-insensitive SGLT1 component of glucose absorption"
Induction of histone H3K4 methylation at the promoter, enhancer, and transcribed regions of the Si and Sglt1 genes in rat jejunum in response to a high-starch/low-fat diet.
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Sglt1 gene expression induced by high-starch diet
"induction of Si and Sglt1 gene expression in rat jejunum by a high-starch/low-fat diet intake is positively associated with histone H3K4 methylation"
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Epigenetic regulation via H3K4 methylation
"Feeding rats the high-starch/low-fat diet induced mono-, di-, and trimethylation of histone H3K4 on the promoter and transcribed regions of the Si and Sglt1 genes"
Deep research report on Slc5a1