DUG1 notes (YFR044C, P43616)

• Cys-Gly metallodipeptidase, peptidase M20A family [UniProt:P43616 "SIMILARITY: Belongs to the peptidase M20A family."].
• Biochemistry: PMID:19346245; PMID:19346245; PMID:19346245
• Genetics/DUG pathway: PMID:17179087
• Role restricted to Cys-Gly cleavage; GSH gamma-glutamyl bond cleaved by (Dug2-Dug3)2 GATase: PMID:22277648; no Dug1-Dug2 heterodimer PMID:22277648
• Location: cytoplasm by GFP PMID:17179087. Mitochondrial calls are organellar proteomics/HTP only.

Curation observations

• Omega peptidase activity IGI rows (from the 2007 degradosome model) MODIFIED to metallodipeptidase activity: Dug1 does not cleave the gamma-glutamyl bond.
• YeastPathways RCA "protein-containing complex" (DUG degradosome) marked over-annotated: heteromeric complex not confirmed.
• proteolysis IBA marked over-annotated (dipeptide, not protein, substrate).