Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension.
Towards a proteome-scale map of the human protein-protein interaction network.
Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.
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BCL2L13 is the mammalian functional homolog of yeast Atg32; it binds LC3 through a WXXI/LIR motif and induces both mitochondrial fragmentation and mitophagy. The BH domains mediate fragmentation while the WXXI motif facilitates mitophagy.
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BCL2L13 induces mitochondrial fragmentation in the absence of DRP1/DNM1L and induces mitophagy in Parkin-deficient cells, placing it in a ubiquitin-independent, Parkin-independent receptor-mediated mitophagy pathway, and it can rescue mitophagy in Atg32-deficient yeast.
Biological properties of the BCL-2 family protein BCL-RAMBO, which regulates apoptosis, mitochondrial fragmentation, and mitophagy.
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BCL-RAMBO/BCL2L13 is an integral mitochondrial outer-membrane protein with BH1-BH4 domains, a BHNo region containing the LC3-interacting region (human LIR WQQI), and a C-terminal transmembrane anchor; it functions as a mitophagy receptor recruiting ATG8-family proteins (LC3/GABARAP) via the LIR motif.
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Phosphorylation near the LIR (Ser272 in mouse numbering) tunes LC3 binding and mitophagic activity; PGAM5 acts as a negative regulator by dephosphorylating BCL2L13, and BCL2L13 is reported to recruit the ULK1 complex to the mitochondrial outer membrane to initiate mitophagy.
BCL2L13 at endoplasmic reticulum-mitochondria contact sites regulates calcium homeostasis to maintain skeletal muscle function.
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BCL2L13 localizes to mitochondria, ER, and mitochondria-associated membranes (ER-mitochondria contact sites) and regulates ER-mitochondria calcium homeostasis; its knockdown alters cytosolic calcium release and mitochondrial calcium uptake without changing the number of ER-mitochondria contact sites, indicating a functional rather than structural contact-site role.
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Loss of Bcl2l13 in zebrafish impairs skeletal muscle structure and function and decreases mitochondrial complex activity, supporting a physiological role in muscle bioenergetics and calcium handling.
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma.
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In glioblastoma, BCL2L13 is upregulated and promotes mitochondrial fission and high mitophagy flux by targeting DNM1L (DRP1) at the Ser616 site, promoting tumor proliferation and invasion; this DNM1L-dependent mechanism is context-specific and contrasts with DRP1-independent fragmentation reported elsewhere.
YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions.
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BCL2L13 was identified by LC-MS/MS as an interacting partner of the inner mitochondrial membrane protease YME1L; YME1L promotes phosphorylation of BCL2L13, strengthening BCL2L13-LC3 binding and enhancing mitophagy to restrain renal tubular epithelial cell senescence in diabetic kidney disease models.
Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma.
BCL2L13 (Bcl-rambo) UniProtKB record Q9BXK5
Manual BCL2L13 curation notes