Generated by analyze.py (propagation, residues, report). Regenerate with uv run --project . python analyze.py all from this directory; fetch timestamps are in results/*.json so this file is byte-reproducible.
All 11 rows of ACTL7B-goa.tsv and all 18 WITH/FROM tokens were parsed from the TSV and resolved. For every token that resolves to a protein, QuickGO was asked what evidence that protein carries for the term being propagated (term plus is_a/part_of descendants).
| GOA row | term | code | WITH/FROM token | resolves to | source's evidence for this term | note |
|---|---|---|---|---|---|---|
| 1 | GO:0005634 nucleus | IBA | CGD:CAL0000196900 |
ARP9 (Candida albicans) Q5A9X7 [TrEMBL] | IBA,IDA,IEA (own experimental: yes) | |
| 1 | GO:0005634 nucleus | IBA | MGI:MGI:1343051 |
Actl7a (Mus musculus) Q9QY84 [Swiss-Prot] | EXP,IBA,IDA,IEA (own experimental: yes) | |
| 1 | GO:0005634 nucleus | IBA | PANTHER:PTN008986520 |
- | - | internal PANTHER tree node, not a protein |
| 1 | GO:0005634 nucleus | IBA | SGD:S000004636 |
ARP9 (Saccharomyces cerevisiae) Q05123 [Swiss-Prot] | IBA,IDA,IEA,IPI (own experimental: yes) | |
| 1 | GO:0005634 nucleus | IBA | UniProtKB:Q57ZL0 |
? (Trypanosoma brucei brucei) Q57ZL0 [TrEMBL] | HTP,IBA,IDA (own experimental: yes) | |
| 2 | GO:0005737 cytoplasm | IBA | MGI:MGI:1343051 |
Actl7a (Mus musculus) Q9QY84 [Swiss-Prot] | EXP,IBA,IDA,IEA,IMP,ISO,ISS (own experimental: yes) | |
| 2 | GO:0005737 cytoplasm | IBA | MGI:MGI:1343053 |
Actl7b (Mus musculus) Q9QY83 [Swiss-Prot] | IBA,IDA (own experimental: yes) | |
| 2 | GO:0005737 cytoplasm | IBA | PANTHER:PTN001377938 |
- | - | internal PANTHER tree node, not a protein |
| 2 | GO:0005737 cytoplasm | IBA | RGD:1304697 |
Actl7a (Rattus norvegicus) Q641W9 [Swiss-Prot] | EXP,IBA,IEA,ISO,ISS (own experimental: yes) | |
| 2 | GO:0005737 cytoplasm | IBA | UniProtKB:Q9Y615 |
ACTL7A (Homo sapiens) Q9Y615 [Swiss-Prot] | IBA,IDA,IEA,IMP,ISS (own experimental: yes) | |
| 3 | GO:0005198 structural molecule activity | IBA | PANTHER:PTN000940351 |
- | - | internal PANTHER tree node, not a protein |
| 3 | GO:0005198 structural molecule activity | IBA | PANTHER:PTN008986528 |
- | - | internal PANTHER tree node, not a protein |
| 4 | GO:0005856 cytoskeleton | IEA | UniProtKB-SubCell:SL-0090 |
- | - | UniProt controlled-vocabulary subcellular-location term, not a protein |
| 5 | GO:0007010 cytoskeleton organization | IEA | GO:0005200 |
- | - | inter-ontology logical inference from another GO term, not a protein |
| 6 | GO:0005515 protein binding | IPI | UniProtKB:O00291 |
HIP1 (Homo sapiens) O00291 [Swiss-Prot] | IBA,IDA,IEA,IPI,TAS (own experimental: yes) | |
| 7 | GO:0005515 protein binding | IPI | UniProtKB:P13473-2 |
LAMP2 (Homo sapiens) P13473 [Swiss-Prot] | IEA,IPI (own experimental: yes) | isoform-level accession P13473-2 |
| 8 | GO:0005515 protein binding | IPI | UniProtKB:P55212 |
CASP6 (Homo sapiens) P55212 [Swiss-Prot] | IPI (own experimental: yes) | |
| 9 | GO:0005515 protein binding | IPI | UniProtKB:P62826 |
RAN (Homo sapiens) P62826 [Swiss-Prot] | IPI (own experimental: yes) |
Read from the cached PAINT table interpro/panther/PTHR11937/PTHR11937-paint.tsv. IRD rows with negated=true are PAINT's own explicit rejections of a term for that clade.
| node | term | aspect | PAINT evidence | seeds |
|---|---|---|---|---|
| PTN000940351 | GO:0005200 | F | IBD | ACT1 (Saccharomyces cerevisiae), ACTR2 (Homo sapiens), Actg1 (Mus musculus), act1 (Dictyostelium discoideum), ARP10 (Saccharomyces cerevisiae), ACTR3 (Homo sapiens), act10 (Dictyostelium discoideum), Actg1 (Rattus norvegicus), ACTB (Homo sapiens), ARP1 (Saccharomyces cerevisiae) |
| PTN001377938 | GO:0005737 | C | IBD | Actl7a (Mus musculus), ACTL7A (Homo sapiens), Actl7a (Rattus norvegicus), Actl7b (Mus musculus) |
| PTN008986520 | GO:0005634 | C | IBD | Actl7a (Mus musculus), ARP9 (Saccharomyces cerevisiae), ? (Trypanosoma brucei brucei), ARP9 (Candida albicans) |
| PTN008986528 | GO:0005198 | F | IBA | PANTHER:PTN000940351 |
| PTN008986528 | GO:0005200 | F | IRD (NEGATED) | PANTHER:PTN000940351 |
Residue sets are computed from deposited structures, then scored across an actin-family panel by global BLOSUM62 alignment. Contact cutoffs: 4.0 A to nucleotide/ion heavy atoms, 4.5 A between protomers.
| accession | gene | UniProt name | status | length | role in this panel | % id to ACTL7B |
|---|---|---|---|---|---|---|
| Q9Y614 | ACTL7B (Homo sapiens) | Actin-like protein 7B | Swiss-Prot | 415 | query (human ACTL7B) | 100.0 |
| Q9QY83 | Actl7b (Mus musculus) | Actin-like protein 7B | Swiss-Prot | 418 | ACTL7 clade: mouse ortholog | 86.7 |
| Q9Y615 | ACTL7A (Homo sapiens) | Actin-like protein 7A | Swiss-Prot | 435 | ACTL7 clade: human paralog | 58.6 |
| Q9QY84 | Actl7a (Mus musculus) | Actin-like protein 7A | Swiss-Prot | 440 | ACTL7 clade: mouse paralog | 58.1 |
| P60709 | ACTB (Homo sapiens) | Actin, cytoplasmic 1 | Swiss-Prot | 375 | conventional actin | 44.3 |
| P68133 | ACTA1 (Homo sapiens) | Actin, alpha skeletal muscle | Swiss-Prot | 377 | conventional actin | 42.4 |
| P60010 | ACT1 (Saccharomyces cerevisiae) | Actin | Swiss-Prot | 375 | conventional actin (yeast) | 43.2 |
| P61160 | ACTR2 (Homo sapiens) | Actin-related protein 2 | Swiss-Prot | 394 | cytoplasmic ARP (Arp2/3 complex) | 35.3 |
| P61158 | ACTR3 (Homo sapiens) | Actin-related protein 3 | Swiss-Prot | 418 | cytoplasmic ARP (Arp2/3 complex) | 29.6 |
| O96019 | ACTL6A (Homo sapiens) | Actin-like protein 6A | Swiss-Prot | 429 | nuclear ARP (SWI/SNF-family) | 29.6 |
| Q9H9F9 | ACTR5 (Homo sapiens) | Actin-related protein 5 | Swiss-Prot | 607 | nuclear ARP (INO80 complex) | 31.1 |
| Q9H981 | ACTR8 (Homo sapiens) | Actin-related protein 8 | Swiss-Prot | 624 | nuclear ARP (INO80 complex) | 25.1 |
| Q05123 | ARP9 (Saccharomyces cerevisiae) | Actin-like protein ARP9 | Swiss-Prot | 467 | nuclear ARP (yeast RSC/SWI-SNF) | 20.2 |
| Q12406 | ARP7 (Saccharomyces cerevisiae) | Actin-related protein 7 | Swiss-Prot | 477 | nuclear ARP (yeast RSC/SWI-SNF) | 24.1 |
Actin chains detected: A; chain analysed: A (373 SEQRES residues). Nucleotide/ion groups: ATP, CA, MG.
nucleotide contacts - 22 positions: [14, 15, 16, 17, 19, 75, 138, 156, 157, 158, 159, 160, 183, 184, 211, 214, 215, 302, 303, 304, 306, 307]
| protein | role | % id to whole structure seq | identical | similar | different | gap | % identical | % id+sim |
|---|---|---|---|---|---|---|---|---|
| ACTL7B (Homo sapiens) | query (human ACTL7B) | 42.6 | 14 | 1 | 7 | 0 | 63.6 | 68.2 |
| Actl7b (Mus musculus) | ACTL7 clade: mouse ortholog | 43.2 | 14 | 1 | 7 | 0 | 63.6 | 68.2 |
| ACTL7A (Homo sapiens) | ACTL7 clade: human paralog | 42.9 | 13 | 3 | 6 | 0 | 59.1 | 72.7 |
| Actl7a (Mus musculus) | ACTL7 clade: mouse paralog | 43.2 | 13 | 2 | 7 | 0 | 59.1 | 68.2 |
| ACTB (Homo sapiens) | conventional actin | 93.3 | 21 | 1 | 0 | 0 | 95.5 | 100.0 |
| ACTA1 (Homo sapiens) | conventional actin | 99.7 | 22 | 0 | 0 | 0 | 100.0 | 100.0 |
| ACT1 (Saccharomyces cerevisiae) | conventional actin (yeast) | 86.6 | 20 | 2 | 0 | 0 | 90.9 | 100.0 |
| ACTR2 (Homo sapiens) | cytoplasmic ARP (Arp2/3 complex) | 48.8 | 19 | 2 | 1 | 0 | 86.4 | 95.5 |
| ACTR3 (Homo sapiens) | cytoplasmic ARP (Arp2/3 complex) | 40.8 | 17 | 4 | 1 | 0 | 77.3 | 95.5 |
| ACTL6A (Homo sapiens) | nuclear ARP (SWI/SNF-family) | 40.2 | 11 | 2 | 9 | 0 | 50.0 | 59.1 |
| ACTR5 (Homo sapiens) | nuclear ARP (INO80 complex) | 33.2 | 9 | 1 | 12 | 0 | 40.9 | 45.5 |
| ACTR8 (Homo sapiens) | nuclear ARP (INO80 complex) | 24.4 | 11 | 4 | 7 | 0 | 50.0 | 68.2 |
| ARP9 (Saccharomyces cerevisiae) | nuclear ARP (yeast RSC/SWI-SNF) | 23.6 | 7 | 4 | 11 | 0 | 31.8 | 50.0 |
| ARP7 (Saccharomyces cerevisiae) | nuclear ARP (yeast RSC/SWI-SNF) | 25.7 | 7 | 4 | 11 | 0 | 31.8 | 50.0 |
Per-position nucleotide contacts in ACTL7B (1ATN numbering -> ACTL7B): G14->G57, S15->S58, G16->Q59, L17->Y60, K19->K62, G75->G118, Q138->Q181, S156->S199, G157->G200, D158->H201, G159->G202, V160->V203, G183->G226, R184->G227, R211->E253, K214->K256, E215->K257, G302->G343, G303->G344, T304->C345, M306->M347, Y307->L348
Actin chains detected: C, A, B, D, E; chain analysed: C (375 SEQRES residues). Nucleotide/ion groups: ADP, PO4, MG.
nucleotide contacts - 20 positions: [13, 14, 15, 16, 18, 137, 156, 157, 158, 159, 182, 210, 213, 214, 301, 302, 303, 305, 306, 336]
| protein | role | % id to whole structure seq | identical | similar | different | gap | % identical | % id+sim |
|---|---|---|---|---|---|---|---|---|
| ACTL7B (Homo sapiens) | query (human ACTL7B) | 42.9 | 13 | 1 | 6 | 0 | 65.0 | 70.0 |
| Actl7b (Mus musculus) | ACTL7 clade: mouse ortholog | 43.5 | 13 | 1 | 6 | 0 | 65.0 | 70.0 |
| ACTL7A (Homo sapiens) | ACTL7 clade: human paralog | 43.2 | 12 | 3 | 5 | 0 | 60.0 | 75.0 |
| Actl7a (Mus musculus) | ACTL7 clade: mouse paralog | 43.7 | 12 | 2 | 6 | 0 | 60.0 | 70.0 |
| ACTB (Homo sapiens) | conventional actin | 93.3 | 19 | 1 | 0 | 0 | 95.0 | 100.0 |
| ACTA1 (Homo sapiens) | conventional actin | 100.0 | 20 | 0 | 0 | 0 | 100.0 | 100.0 |
| ACT1 (Saccharomyces cerevisiae) | conventional actin (yeast) | 86.7 | 18 | 2 | 0 | 0 | 90.0 | 100.0 |
| ACTR2 (Homo sapiens) | cytoplasmic ARP (Arp2/3 complex) | 48.3 | 17 | 2 | 1 | 0 | 85.0 | 95.0 |
| ACTR3 (Homo sapiens) | cytoplasmic ARP (Arp2/3 complex) | 40.8 | 14 | 5 | 1 | 0 | 70.0 | 95.0 |
| ACTL6A (Homo sapiens) | nuclear ARP (SWI/SNF-family) | 40.5 | 9 | 3 | 8 | 0 | 45.0 | 60.0 |
| ACTR5 (Homo sapiens) | nuclear ARP (INO80 complex) | 32.8 | 8 | 1 | 11 | 0 | 40.0 | 45.0 |
| ACTR8 (Homo sapiens) | nuclear ARP (INO80 complex) | 24.3 | 10 | 5 | 5 | 0 | 50.0 | 75.0 |
| ARP9 (Saccharomyces cerevisiae) | nuclear ARP (yeast RSC/SWI-SNF) | 23.5 | 7 | 3 | 10 | 0 | 35.0 | 50.0 |
| ARP7 (Saccharomyces cerevisiae) | nuclear ARP (yeast RSC/SWI-SNF) | 25.9 | 7 | 4 | 9 | 0 | 35.0 | 55.0 |
protomer-protomer interface - 74 positions: [38, 39, 40, 41, 42, 43, 44, 45, 49, 50, 53, 60, 61, 62, 63, 64, 65, 66, 110, 111, 112, 113, 114, 139, 142, 143, 147, 148, 165, 166, 167, 168, 169, 170, 171, 172, 173, 191, 194, 195, 196, 197, 202, 203, 204, 205, 208, 241, 242, 243, 244, 245, 246, 267, 268, 269, 270, 283, 286, 287, 288, 289, 290, 291, 294, 322, 324, 325, 346, 349, 351, 352, 355, 375]
| protein | role | % id to whole structure seq | identical | similar | different | gap | % identical | % id+sim |
|---|---|---|---|---|---|---|---|---|
| ACTL7B (Homo sapiens) | query (human ACTL7B) | 42.9 | 26 | 13 | 34 | 1 | 35.1 | 52.7 |
| Actl7b (Mus musculus) | ACTL7 clade: mouse ortholog | 43.5 | 25 | 13 | 35 | 1 | 33.8 | 51.4 |
| ACTL7A (Homo sapiens) | ACTL7 clade: human paralog | 43.2 | 31 | 12 | 31 | 0 | 41.9 | 58.1 |
| Actl7a (Mus musculus) | ACTL7 clade: mouse paralog | 43.7 | 30 | 12 | 32 | 0 | 40.5 | 56.8 |
| ACTB (Homo sapiens) | conventional actin | 93.3 | 72 | 2 | 0 | 0 | 97.3 | 100.0 |
| ACTA1 (Homo sapiens) | conventional actin | 100.0 | 74 | 0 | 0 | 0 | 100.0 | 100.0 |
| ACT1 (Saccharomyces cerevisiae) | conventional actin (yeast) | 86.7 | 62 | 11 | 1 | 0 | 83.8 | 98.6 |
| ACTR2 (Homo sapiens) | cytoplasmic ARP (Arp2/3 complex) | 48.3 | 32 | 11 | 31 | 0 | 43.2 | 58.1 |
| ACTR3 (Homo sapiens) | cytoplasmic ARP (Arp2/3 complex) | 40.8 | 22 | 11 | 41 | 0 | 29.7 | 44.6 |
| ACTL6A (Homo sapiens) | nuclear ARP (SWI/SNF-family) | 40.5 | 30 | 12 | 32 | 0 | 40.5 | 56.8 |
| ACTR5 (Homo sapiens) | nuclear ARP (INO80 complex) | 32.8 | 20 | 9 | 40 | 5 | 27.0 | 39.2 |
| ACTR8 (Homo sapiens) | nuclear ARP (INO80 complex) | 24.3 | 23 | 17 | 34 | 0 | 31.1 | 54.1 |
| ARP9 (Saccharomyces cerevisiae) | nuclear ARP (yeast RSC/SWI-SNF) | 23.5 | 15 | 15 | 35 | 9 | 20.3 | 40.5 |
| ARP7 (Saccharomyces cerevisiae) | nuclear ARP (yeast RSC/SWI-SNF) | 25.9 | 17 | 15 | 36 | 6 | 23.0 | 43.2 |
Per-position nucleotide contacts in ACTL7B (8A2S numbering -> ACTL7B): G13->G57, S14->S58, G15->Q59, L16->Y60, K18->K62, Q137->Q181, G156->G200, D157->H201, G158->G202, V159->V203, G182->G226, R210->E253, K213->K256, E214->K257, G301->G343, G302->G344, T303->C345, M305->M347, Y306->L348, K336->K377
Interface contacts broken into contiguous segments (segments are derived from the contact positions themselves, not from named literature regions):
| segment | n | actin residues | ACTL7B residues | identical ACTL7B | identical ACTL7A | identical ACTB |
|---|---|---|---|---|---|---|
| 38-45 | 8 | PRHQGVMV | RCPEAADA | 0/8 | 1/8 | 8/8 |
| 49-50 | 2 | QK | RK | 1/2 | 1/2 | 2/2 |
| 53 | 1 | Y | L | 0/1 | 0/1 | 1/1 |
| 60-66 | 7 | SKRGILT | NTEAPLK | 1/7 | 1/7 | 7/7 |
| 110-114 | 5 | LNPKA | LSPSS | 2/5 | 2/5 | 5/5 |
| 139 | 1 | V | L | 0/1 | 0/1 | 1/1 |
| 142-143 | 2 | LY | IY | 1/2 | 1/2 | 2/2 |
| 147-148 | 2 | RT | KT | 1/2 | 2/2 | 2/2 |
| 165-173 | 9 | IYEGYALPH | ISEGDVLPG | 5/9 | 7/9 | 9/9 |
| 191 | 1 | K | Q | 0/1 | 0/1 | 1/1 |
| 194-197 | 4 | TERG | NEAG | 2/4 | 1/4 | 4/4 |
| 202-205 | 4 | TTAE | TDDH | 1/4 | 1/4 | 4/4 |
| 208 | 1 | I | I | 1/1 | 1/1 | 1/1 |
| 241-246 | 6 | ELPDGQ | ELPDGK | 5/6 | 4/6 | 6/6 |
| 267-270 | 4 | IGME | AGST | 1/4 | 1/4 | 3/4 |
| 283 | 1 | M | G | 0/1 | 0/1 | 1/1 |
| 286-291 | 6 | DIDIRK | DTGFKE | 1/6 | 2/6 | 5/6 |
| 294 | 1 | Y | A | 0/1 | 0/1 | 1/1 |
| 322-325 | 3 | PTM | PDS | 1/3 | 2/3 | 3/3 |
| 346 | 1 | L | L | 1/1 | 1/1 | 1/1 |
| 349-352 | 3 | LTF | LAF | 2/3 | 2/3 | 3/3 |
| 355 | 1 | M | L | 0/1 | 0/1 | 1/1 |
| 375 | 1 | F | - | 0/1 | 1/1 | 1/1 |