Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1.
A mosquito salivary protein inhibits activation of the plasma contact system by binding to factor XII and high molecular weight kininogen.
Identification and characterization of plasma kallikrein-kinin system inhibitors from salivary glands of the blood-sucking insect Triatoma infestans.
Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation.
Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Coagulation factor XII (Hageman factor) Washington D.C.: inactive factor XIIa results from Cys-571----Ser substitution.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Ayaconin, a novel inhibitor of the plasma contact system from the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis.
Isolation and properties of an abnormal Hageman factor (Factor XII) molecule in a cross-reacting material-positive hageman trait plasma.
Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R).
Hageman-factor-dependent fibrinolysis: generation of fibrinolytic activity by the interaction of human activated factor XI and plasminogen.
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
factor XII -> factor XIIa
factor XIIa binds SERPING1
SERPING1 variant does not bind factor XIIa
Cleavage of factor XII variant by activated thrombin
Cleavage of FXII variant by KLKB1
FXIIa is cleaved to β-FXIIa
prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst)
factor XII + prekallikrein:kininogen:cell surface receptor -> prekallikrein:kininogen:cell surface receptor:factor XII
factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma)
factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis)
prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface)
kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst)
prekallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor:factor XII (FXII catalyst)
factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst)
factor XII:β-amyloid:Zn2+-> factor XIIa + β-amyloid:Zn2+ (autocatalysis)
factor XII + β-amyloid fibril:Zn2+ -> factor XII:β-amyloid fibril:Zn2+
FXIIa activates plasma kallikrein-kinin system
Identification of the histidine-rich glycoprotein domains responsible for contact pathway inhibition.
Immunohistochemical localization of hepatocyte growth factor activator (HGFA) in developing mouse liver tissues. Heterogeneous distribution of HGFA protein.
Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo.