Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
Draculin, the anticoagulant factor in vampire bat saliva, is a tight-binding, noncompetitive inhibitor of activated factor X.
Dracula's children: molecular evolution of vampire bat venom.
Purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (Desmodus rotundus).
Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule.
Deep research report on K9IMD0/LTF/draculin (Falcon/Edison Scientific Literature)
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UniProt K9IMD0 maps to a Desmodus rotundus lactotransferrin (LTF) scaffold detected in submaxillary salivary gland proteomes; later omics places "draculin" on this LTF scaffold but lacks recombinant confirmation that the canonical LTF protein is itself the salivary anticoagulant, so the relationship between LTF identity and the historical draculin anti-FIXa/anti-FXa activity should be treated as draft-level rather than fully resolved.
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Conserved mammalian lactoferrin family biology (iron binding via two N/C-lobe Fe3+ sites, antimicrobial activity through iron sequestration and LPS binding, immunomodulation via TLR4/LRP1/TRAF6/NF-kB signaling, and proteolytic/antiviral activities) provides high-confidence homology-based inference for K9IMD0, but these functions have not been directly assayed for the vampire-bat protein.
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Draculin anticoagulant activity is strictly glycosylation-dependent (chemical deglycosylation abolishes anti-FXa activity, Fernandez 1998), so any LTF-based explanation of draculin would require intact N-linked glycans; recombinant unglycosylated LTF would not be expected to reproduce the salivary anticoagulant phenotype.
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Anticoagulant specialization does not establish loss of conserved iron handling or innate defense; exact mapping of native draculin activity remains a separate caveat.
"These functions are **not directly assayed** for the vampire-bat LTF/draculin sequence in the retrieved bat-specific studies; they are best treated as **high-confidence inference from the conserved lactotransferrin scaffold**."
Focused OpenScientist report on K9IMD0 lactotransferrin carry-over and draculin specialization
UniProtKB K9IMD0 lactotransferrin record
The "Vampirome": Transcriptome and proteome analysis of the principal and accessory submaxillary glands of the vampire bat Desmodus rotundus, a vector of human rabies.