VAL1 (Q8W4L5, At2g30470; HSI2) curation notes

2026-10-06 initial review

• Deep research: just deep-research-falcon ARATH VAL1 failed (HTTP 402 from provider); review built from cached publications and UniProt.
• Added references (cached via just fetch-gene-pmids): PMID:29660015 (VAL1 B3-DNA crystal structure, full text), PMID:27819666 (cold memory element / VAL1-VAL2 readers, abstract), PMID:36130923 (VAL1 assembly platform, full text).
• Architecture: B3 domain, PHD-like, CW-type zinc finger, EAR motif. Active repressor PMID:15894743.
• Sequence-specific DNA binding: B3 recognises Sph/RY PMID:29660015. Added NEW GO:0043565 (IDA).
• Vernalization: VAL1 binds the FLC nucleation region and triggers PHD-PRC2 nucleation PMID:27471304; PMID:27819666. Added NEW GO:0010048 involved_in: VAL1 performs a step (targeting/recruitment), not merely necessity.
• PRC2 recruitment genome-wide PMID:33270882. Bare protein-binding rows to CLF, SWN, PYL9 removed per policy (no PRC2-binding MF term exists); SNL1 row -> transcription corepressor binding.
• Mitochondrion HDA (large proteome) -> MARK_AS_OVER_ANNOTATED (nuclear TF, likely co-purification).
• Core MF GO:0043565 matches the module vernalization_flc_silencing annoton for VAL1.