Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.
GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization.
Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.
The sonic hedgehog-patched-gli pathway in human development and disease.
Physical and functional interactions between Zic and Gli proteins.
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3.
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing.
Mediator modulates Gli3-dependent Sonic hedgehog signaling.
Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling.
Characterization of the interactions of human ZIC3 mutants with GLI3.
CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.
Hydrometrocolpos, postaxial polydactyly, and hypothalamic hamartoma in a patient with confirmed Pallister-Hall syndrome: a clinical overlap with McKusick-Kaufman syndrome.
Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3.
Identification of the gene transcription repressor domain of Gli3.
Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3.
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase.
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.
GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.
Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.
Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.
WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.
Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.
Human transcription factor protein interaction networks.
Mutation in GLI3 in postaxial polydactyly type A.
CK1 phosphorylates p-GLI3
GSK3 phosphorylates p-GLI3
SCF(beta-TrCP) ubiquitinates p-GLI3
GLI3R translocates to the nucleus
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base
The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip
GLI3R binds the PTCH1 promoter
GLI3R binds the GLI1 promoter
GLI3R binds the GLI2 promoter
GLI proteins are phosphorylated
GLI translocates to the nucleus
GLI proteins bind GLI1 gene
GLI proteins bind PTCH1 gene
GLI2,3 are degraded by the proteasome
phosphorylated GLI proteins bind SPOP:CUL3:RBX1
SPOP:CUL3:RBX1 ubiquitinates GLI2,3
GLI:SUFU translocates to the ciliary tip in response to Hh signaling
Gli proteins encode context-dependent positive and negative functions: implications for development and disease.
The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.
GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning.
The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms.
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.
Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.