Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis.
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MKS-5 localizes to the ciliary transition zone
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MKS-5 is a central component required for docking/anchoring MKS and NPHP protein modules
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MKS/NPHP proteins establish basal body/TZ membrane attachments before or coinciding with IFT-dependent axoneme extension
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Joint disruption of MKS and NPHP modules results in BB/TZ membrane association defects
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TZ proteins establish a ciliary gate that modulates ciliary composition
Caenorhabditis elegans ciliary protein NPHP-8, the homologue of human RPGRIP1L, is required for ciliogenesis and chemosensation.
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NPHP-8/MKS-5 co-localizes with NPHP-4 at the transition zone at the base of cilia
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nphp-8 mutants show abnormal dye filling (Dyf) and shorter cilia lengths in a subset of ciliary neurons
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Chemotaxis to several volatile attractants is significantly impaired in nphp-8 mutants
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NPHP-8/RPGRIP1L plays an important role in cilia formation and cilia-mediated chemosensation
Diverse cell type-specific mechanisms localize G protein-coupled receptors to Caenorhabditis elegans sensory cilia.
A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4.
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yhw91 identified as novel mks-5 allele in genetic screen
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mks-5, mks-1, and mks-2 are among modifiers of nphp-4 ciliary phenotypes
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mks-5 genetically interacts with nphp-4 in ciliogenesis
MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone.
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CEP-290 depends on the coiled coil region of MKS-5 for TZ localization
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TMEM-218 depends on MKS-5 and MKS-2 for transition zone localization
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MKS-5 and CEP-290 define an assembly pathway for building a functional TZ
A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
Deep research report on mks-5